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Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy 期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:  Hua, Chen;  Shena, Lijuan;  Zoua, Fengming;  Wua, Yun;  Wanga, Beilei;  Wanga, Aoli;  Wud, Chao;  Wanga, Li;  Liua, Jing;  Wanga, Wenchao;  Liua, Qingsong
收藏  |  浏览/下载：34/0  |  提交时间：2023/11/10
Acquired resistance mutations  CDK9 inhibitors  Transcription  Single nucleotide polymorphisms  BAY1251152  
Protein degradation technology: a strategic paradigm shift in drug discovery 期刊论文
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 卷号: 14
作者:  Li, Haobin;  Dong, Jinyun;  Cai, Maohua;  Xu, Zhiyuan;  Cheng, Xiang-Dong;  Qin, Jiang-Jiang
收藏  |  浏览/下载：61/0  |  提交时间：2021/11/01
Protein degradation  Degradation pathway  Degradation technology  PROTAC  Monomeric degraders  
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
作者:  Wang, Beilei;  Wu, Jiaxin;  Wu, Yun;  Chen, Cheng;  Zou, Fengming;  Wang, Aoli;  Wu, Hong;  Hu, Zhenquan;  Jiang, Zongru;  Liu, Qingwang;  Wang, Wei;  Zhang, Yicong;  Liu, Feiyang;  Zhao, Ming;  Hu, Jie;  Huang, Tao;  Ge, Juan;  Wang, Li;  Ren, Tao;  Wang, Yuxin;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：25/0  |  提交时间：2019/12/25
CDK9  Kinase inhibitor  Structure-activity relationship  Leukemia  
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway 期刊论文
Nature Communications, 2017
作者:  Ma, Xiaoyu;  Wang, Lin;  Huang, De;  Li, Yunyan;  Yang, Dongdong;  Li, Tingting;  Li, Fudong;  Sun, Linchong;  Wei, Haoran;  He, Kun;  Yu, Fazhi;  Zhao, Debiao;  Hu, Lan;  Xing, Songge;  Liu, Zhaoji;  Li, Kui;  Guo, Jing;  Yang, Zhenye;  Pan, Xin;  Li, Ailing;  Shi, Yunyu;  Wang, Junfeng;  Gao, Ping;  Zhang, Huafeng
浏览  |  Adobe PDF(1933Kb)  |  收藏  |  浏览/下载：84/38  |  提交时间：2020/10/22
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway 期刊论文
NATURE COMMUNICATIONS, 2017, 卷号: 8, 期号: 无, 页码: 15
作者:  Ma, Xiaoyu;  Wang, Lin;  Huang, De;  Li, Yunyan;  Yang, Dongdong;  Li, Tingting;  Li, Fudong;  Sun, Linchong;  Wei, Haoran;  He, Kun;  Yu, Fazhi;  Zhao, Debiao;  Hu, Lan;  Xing, Songge;  Liu, Zhaoji;  Li, Kui;  Guo, Jing;  Yang, Zhenye;  Pan, Xin;  Li, Ailing;  Shi, Yunyu;  Wang, Junfeng;  Gao, Ping;  Zhang, Huafeng
浏览  |  Adobe PDF(1933Kb)  |  收藏  |  浏览/下载：92/43  |  提交时间：2019/02/28
高尔基体蛋白STK16和G蛋白GNG7在有丝分裂和膜转运中的功能研究 学位论文
, 合肥: 中国科学技术大学, 2017
作者:  刘娟娟
Adobe PDF(6840Kb)  |  收藏  |  浏览/下载：50/3  |  提交时间：2018/01/18
Kinases Involved in Both Autophagy and Mitosis 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 卷号: 18, 期号: 9, 页码: 1-15
作者:  Li, Zhiyuan;  Zhang, Xin
浏览  |  Adobe PDF(277Kb)  |  收藏  |  浏览/下载：104/47  |  提交时间：2018/08/17
Kinases  Autophagy  Mitosis  Cyclin-dependent Kinases  Aurora  Polo-like Kinases  
STK16 regulates actin dynamics to control Golgi organization and cell cycle 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: 无, 页码: 1-17
作者:  Liu, Juanjuan;  Yang, Xingxing;  Li, Binhua;  Wang, Junjun;  Wang, Wenchao;  Liu, Jing;  Liu, Qingsong;  Zhang, Xin
浏览  |  Adobe PDF(3465Kb)  |  收藏  |  浏览/下载：95/47  |  提交时间：2018/07/04
The Protein Neddylation Pathway in Trypanosoma brucei FUNCTIONAL CHARACTERIZATION AND SUBSTRATE IDENTIFICATION 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 卷号: 292, 期号: 3, 页码: 1081-+
作者:  Liao, Shanhui;  Hu, Huiqing;  Wang, Tao;  Tu, Xiaoming;  Li, Ziyin
浏览  |  Adobe PDF(2776Kb)  |  收藏  |  浏览/下载：101/57  |  提交时间：2018/07/04
基于大肠杆菌-秀丽隐杆线虫二元食物链体系的纳米银生物有效性研究 学位论文
, 合肥: 中国科学技术大学, 2017
作者:  罗勋
Adobe PDF(4697Kb)  |  收藏  |  浏览/下载：39/2  |  提交时间：2018/01/17