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A nanoselenium-coating biomimetic cytomembrane nanoplatform for mitochondrial targeted chemotherapy- and chemodynamic therapy through manganese and doxorubicin codelivery 期刊论文
JOURNAL OF NANOBIOTECHNOLOGY, 2021, 卷号: 19
Authors:  Xiao, Jianmin;  Yan, Miao;  Zhou, Ke;  Chen, Hui;  Xu, Zhaowei;  Gan, Yuehao;  Hong, Biao;  Tian, Geng;  Qian, Junchao;  Zhang, Guilong;  Wu, Zhengyan
Favorite  |  View/Download:8/0  |  Submit date:2021/08/30
Cell membrane  Reactive oxygen species  Superoxide dismutase-1  Glutathione peroxidase 4  Dual-mode therapeutic pathways  Drug delivery system  
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892
Authors:  Liang, Xiaofei;  Wang, Beilei;  Chen, Cheng;  Wang, Aoli;  Hu, Chen;  Zou, Fengming;  Yu, Kailin;  Liu, Qingwang;  Li, Feng;  Hu, Zhenquan;  Lu, Tingting;  Wang, Junjie;  Wang, Li;  Weisberg, Ellen L.;  Li, Lili;  Xia, Ruixiang;  Wang, Wenchao;  Ren, Tao;  Ge, Jian;  Liu, Jing;  Liu, Qinsong
View  |  Adobe PDF(13868Kb)  |  Favorite  |  View/Download:298/289  |  Submit date:2020/05/21
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
Authors:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
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ABL kinase  Kinase inhibitor  ABL mutant  CML  
Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems 期刊论文
CURRENT MEDICINAL CHEMISTRY, 2018, 卷号: 25, 期号: 25, 页码: 3036-3057
Authors:  Sun, Xiao;  Zhang, Guilong;  Wu, Zhengyan
View  |  Adobe PDF(4176Kb)  |  Favorite  |  View/Download:24/11  |  Submit date:2019/12/25
pH-responsive  magnetic resonance contrast agents  drug delivery systems  contrast enhancement  controlled release  cancer diagnosis and chemotherapy  
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
Authors:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
View  |  Adobe PDF(12656Kb)  |  Favorite  |  View/Download:21145/11438  |  Submit date:2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
新型不可逆BTK激酶抑制剂的发现研究 学位论文
, 北京: 中国科学院研究生院, 2017
Authors:  邓远欣
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Interaction between bacterial cell membranes and nano-TiO2 revealed by two-dimensional FTIR correlation spectroscopy using bacterial ghost as a model cell envelope 期刊论文
WATER RESEARCH, 2017, 卷号: 118, 期号: 无, 页码: 104-113
Authors:  Huang, Guocheng;  Ng, Tsz Wai;  An, Taicheng;  Li, Guiying;  Wang, Bo;  Wu, Dan;  Yip, Ho Yin;  Zhao, Huijun;  Wong, Po Keung
View  |  Adobe PDF(2387Kb)  |  Favorite  |  View/Download:27/16  |  Submit date:2018/05/25
Titanium Dioxide Nanoparticles  Bacterial Ghosts  Two-dimensional Ftir Correlation  Nanoparticle-cell Membrane Interaction  
A pH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode Magnetic Resonance Imaging and Chemotherapy 期刊论文
ACS NANO, 2017, 卷号: 11, 期号: 7, 页码: 7049-7059
Authors:  Sun, Xiao;  Du, Ruohong;  Zhang, Li;  Zhang, Guilong;  Zheng, Xiaojia;  Qian, Junchao;  Tian, Xiaohe;  Zhou, Jiewen;  He, Jiacai;  Wang, Yuanyin;  Wu, Yiqun;  Zhong, Kai;  Cai, Dongqing;  Zou, Duohong;  Wu, Zhengyan
View  |  Adobe PDF(2865Kb)  |  Favorite  |  View/Download:89/4  |  Submit date:2018/08/16
Yolk-like Fe3o4@gd2o3  Targeted  Dual-mode Mr Imaging Drug Delivery System  Cisplatin  Ph Responsive  Cancer Chemotherapy  
基于FGF21结构的药物设计及配体与受体的相互作用研究 学位论文
, 合肥: 中国科学技术大学, 2017
Authors:  赵宏鑫
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针对FLT3-ITD阳性急性髓细胞白血病的激酶抑制剂药物学研究 学位论文
, 合肥: 中国科学技术大学, 2017
Authors:  王傲莉
Adobe PDF(7111Kb)  |  Favorite  |  View/Download:102/0  |  Submit date:2018/01/18