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HER2 exon 20 insertion mutations in lung adenocarcinoma with leptomeningeal metastasis: a case report and response to poziotinib 期刊论文
ANNALS OF PALLIATIVE MEDICINE, 2022, 卷号: 11
作者:  Fan, Ying;  Qin, Jing;  Han, Na;  Lu, Hongyang
收藏  |  浏览/下载：26/0  |  提交时间：2022/12/23
Leptomeningeal metastasis (LM)  cerebrospinal fluid  HER2 exon 20 insertion mutations  poziotinib  case report  
Cardiotoxicity of Epidermal Growth Factor Receptor 2-Targeted Drugs for Breast Cancer 期刊论文
FRONTIERS IN PHARMACOLOGY, 2021, 卷号: 12
作者:  Yang, ZiYan;  Wang, Wei;  Wang, Xiaojia;  Qin, ZhiQuan
收藏  |  浏览/下载：61/0  |  提交时间：2022/01/10
cardiotoxicity  ErbB2  targeting drugs  breast cancer  therapy  
The genomic landscape of young and old lung cancer patients highlights age-dependent mutation frequencies and clinical actionability in young patients 期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2021
作者:  Cai, Lei;  Chen, Yong;  Tong, Xiaoling;  Wu, Xue;  Bao, Hua;  Shao, Yang;  Luo, Zhuang;  Wang, Xuming;  Cao, Yang
收藏  |  浏览/下载：71/0  |  提交时间：2021/06/15
EGFR  ERBB2  gene fusions  tyrosine kinase inhibitors  young lung cancer patients  
Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder 期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6
作者:  Liu, Fatao;  Li, Yongsheng;  Ying, Dongjian;  Qiu, Shimei;  He, Yong;  Li, Maolan;  Liu, Yun;  Zhang, Yijian;  Zhu, Qin;  Hu, Yunping;  Liu, Liguo;  Li, Guoqiang;  Pan, Weihua;  Jin, Wei;  Mu, Jiasheng;  Cao, Yang;  Liu, Yingbin
收藏  |  浏览/下载：42/0  |  提交时间：2021/04/26
Integrated Analyses Identify Immune-Related Signature Associated with Qingyihuaji Formula for Treatment of Pancreatic Ductal Adenocarcinoma Using Network Pharmacology and Weighted Gene Co-Expression Network 期刊论文
JOURNAL OF IMMUNOLOGY RESEARCH, 2020, 卷号: 2020
作者:  Qian, Xiang;  Chen, Zhuo;  Chen, Sha Sha;  Liu, Lu Ming;  Zhang, Ai Qin
收藏  |  浏览/下载：41/0  |  提交时间：2020/11/26
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627
作者:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang;  Geng, Meiyu;  Ding, Jian;  Liu, Qingsong;  Sun, Liping;  Xie, Hua;  Zhang, Ao
浏览  |  Adobe PDF(6587Kb)  |  收藏  |  浏览/下载：147/106  |  提交时间：2019/08/23
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21275/11466  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxybenzamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 1793-1816
作者:  Liang, Xiaofei;  Lv, Fengchao;  Wang, Beilei;  Yu, Kailin;  Wu, Hong;  Qi, Ziping;  Jiang, Zongru;  Chen, Cheng;  Wang, Aoli;  Miao, Weili;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Liu, Xiaochuan;  Zhao, Zheng;  Wang, Li;  Zhang, Shanchuan;  Ye, Zi;  Wang, Chu;  Ren, Tao;  Wang, Yinsheng;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5919Kb)  |  收藏  |  浏览/下载：17293/7523  |  提交时间：2018/07/04
Development of dual-fluorescence cell-based biosensors for detecting the influence of environmental factors on nanoparticle toxicity 期刊论文
CHEMOSPHERE, 2017, 卷号: 171, 期号: 无, 页码: 177-184
作者:  Liang, Junting;  Wang, Xuanyu;  Li, Luzhi;  Xu, Shengmin;  Jiang, Jiang;  Wu, Lijun;  Zhao, Guoping;  Chen, Shaopeng
浏览  |  Adobe PDF(1137Kb)  |  收藏  |  浏览/下载：106/26  |  提交时间：2018/07/04
Biosensor  Fluorescent Protein  Nanoparticles  Environmental Factor  Flow Cytometry  
一种高活性高选择性Type Ⅱ不可逆 BMX 激酶抑制剂的开发 学位论文
, 合肥: 中国科学技术大学, 2017
作者:  吕凤超
Adobe PDF(2693Kb)  |  收藏  |  浏览/下载：46/0  |  提交时间：2018/01/18