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Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243
作者:  Liang, Xiaofei;  Wang, Chun;  Wang, Beilei;  Liu, Juan;  Qi, Shuang;  Wang, Aoli;  Liu, Qingwang;  Deng, Maoqing;  Wang, Li;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：40/0  |  提交时间：2022/12/23
CSF1R inhibitor  Kinase inhibitor  Macrophage polarization  
Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2 期刊论文
LEUKEMIA, 2022
作者:  Yang, Jing;  Weisberg, Ellen L.;  Qi, Shuang;  Ni, Wei;  Mei, Husheng;  Wang, Zuowei;  Meng, Chengcheng;  Zhang, Shengzhe;  Hou, Mingqi;  Qi, Ziping;  Wang, Aoli;  Jiang, Yunyun;  Jiang, Zongru;  Huang, Tao;  Liu, Qingwang;  Magin, Robert S.;  Doherty, Laura;  Wang, Wenchao;  Liu, Jing;  Buhrlage, Sara J.;  Liu, Qingsong;  Griffin, James D.
收藏  |  浏览/下载：76/0  |  提交时间：2022/02/14
Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent 期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10
作者:  Jiang, Zongru;  Wang, Li;  Liu, Xuesong;  Chen, Cheng;  Wang, Beilei;  Wang, Wenliang;  Hu, Chen;  Yu, Kailin;  Qi, Ziping;  Liu, Qingwang;  Wang, Aoli;  Liu, Jing;  Hong, Guangchen;  Wang, Wenchao;  Liu, Qingsong
收藏  |  浏览/下载：51/0  |  提交时间：2020/11/26
Cancer  VEGFR2 kinase  Kinase inhibitor  Angiogenesis  Inhibitor selectivity  
Discovery of 6 '-chloro-N-methyl-5 '-(phenylsulfonamido)-[3,3 '-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188
作者:  Liang, Xiaofei;  Jiang, Zongru;  Huang, Zhenghui;  Li, Feng;  Chen, Cheng;  Hu, Chen;  Wang, Wenliang;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Qi, Ziping;  Liu, Jing;  Jiang, Lubin;  Liu, Qingsong
收藏  |  浏览/下载：55/0  |  提交时间：2020/11/26
PI4K kinase  Kinase inhibitor  Malaria  Blood stage  Liver stage  
Synthesis of disulfide surrogate peptides incorporating large-span surrogate bridges through a native chemical ligation-assisted diaminodiacid strategy 期刊论文
Angewandte International Edition A Journal of the Gesellschaft Deutscher Chemiker www.angewandte.org Chemie, 2020
作者:  Qian Qu;  Shuai Gao;  Fangming Wu;  Meng-Ge Zhang;  Ying Li;  Long-Hua Zhang;  Donald Bierer;  Chang-Lin Tian;  Ji-Shen Zheng;  Lei Liu
浏览  |  Adobe PDF(4926Kb)  |  收藏  |  浏览/下载：69/33  |  提交时间：2020/10/26
Phosphorylation-Dependent SERS Readout for Activity Assay of Protein Kinase A in Cell Extracts 期刊论文
Nanomaterials, 2020
作者:  Renyong Liu;  Chenggen Xie;  Yehan Yan;  Lin Hu;  Suhua Wang;  Khalid A. Alamry;  Hadi M. Marwani;  Lijuan Chen
浏览  |  Adobe PDF(1513Kb)  |  收藏  |  浏览/下载：60/30  |  提交时间：2020/10/20
Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
作者:  Wu, Jiaxin;  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Qi, Ziping;  Hu, Chen;  Wang, Wenliang;  Wu, Hong;  Huang, Tao;  Zhao, Ming;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Li, Lili;  Ge, Jian;  Ren, Tao;  Xia, Ruixiang;  Liu, Jing
收藏  |  浏览/下载：52/0  |  提交时间：2019/11/27
BCR-ABL  PDGFR  chronic myeloid leukemia  kinase inhibitor  
Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019
作者:  Yun Wu;  Beilei Wang;  Junjie Wang;  Qi S(亓爽);  Fengming Zou;  Ziping Qi;  Feiyang Liu;  Wenchao Wang;  Qingsong Liu;  Jing Liu
浏览  |  Adobe PDF(5207Kb)  |  收藏  |  浏览/下载：124/63  |  提交时间：2020/10/20
A graphene oxide-based hairpin probe coupling duplex-specific nuclease signal amplification for detection and imaging of mRNA in living cells 期刊论文
TALANTA, 2019, 卷号: 195, 期号: 无, 页码: 732-738
作者:  Xu, Wei;  Zhao, Aiwu;  Zuo, Fangtao;  Hussain, Hafiz Muhammad Jafar
浏览  |  Adobe PDF(3681Kb)  |  收藏  |  浏览/下载：90/43  |  提交时间：2020/05/21
Duplex-specific nuclease  Hairpin probe  Graphene oxide  Signal amplification  Target mRNA  Living cells imaging  
A facile stage for Cu2+ ions detection by formation and aggregation of Cu nanoclusters 期刊论文
MICROCHEMICAL JOURNAL, 2019, 卷号: 145, 期号: 无, 页码: 517-522
作者:  Shen, Zhi;  Zhang, Cheng;  Yu, Xinling;  Li, Jian;  Liu, Bianhua;  Zhang, Zhongping
浏览  |  Adobe PDF(1245Kb)  |  收藏  |  浏览/下载：55/9  |  提交时间：2020/05/21
Nanoclusters  Aggregation  Copper ions  Fluorescence