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Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
Authors:  Wu, Jiaxin;  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Qi, Ziping;  Hu, Chen;  Wang, Wenliang;  Wu, Hong;  Huang, Tao;  Zhao, Ming;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Li, Lili;  Ge, Jian;  Ren, Tao;  Xia, Ruixiang;  Liu, Jing
Favorite  |  View/Download:3/0  |  Submit date:2019/11/27
BCR-ABL  PDGFR  chronic myeloid leukemia  kinase inhibitor  
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
Authors:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
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ABL kinase  Kinase inhibitor  ABL mutant  CML  
Targeting Nrf2-mediated heme oxygenase-1 enhances non-thermal plasma-induced cell death in non-small-cell lung cancer A549 cells 期刊论文
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2018, 卷号: 658, 页码: 54-65
Authors:  Ma, Jie;  Yu, K. N.;  Cheng, Cheng;  Ni, Guohua;  Shen, Jie;  Han, Wei
Adobe PDF(4120Kb)  |  Favorite  |  View/Download:22/6  |  Submit date:2019/01/11
Non-thermal plasma  Reactive oxygen species  Heme oxygenase-1  Apoptotic death  c-JUN N-terminal kinase  
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3K delta) inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 156, 页码: 831-846
Authors:  Liang, Xiaofei;  Li, Feng;  Chen, Cheng;  Jiang, Zongru;  Wang, Aoli;  Liu, Xiaochuan;  Ge, Juan;  Hu, Zhenquan;  Yu, Kailin;  Wang, Wenliang;  Zou, Fengming;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Zhang, Shanchun;  Wang, Yuxin;  Liu, Qingsong;  Liu, Jing
Favorite  |  View/Download:0/0  |  Submit date:2019/12/10
PI3K delta  Kinase inhibitor  Acute myeloid leukemia  Structure-activity relationship  
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627
Authors:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang;  Geng, Meiyu;  Ding, Jian;  Liu, Qingsong;  Sun, Liping;  Xie, Hua;  Zhang, Ao
View  |  Adobe PDF(6587Kb)  |  Favorite  |  View/Download:4/0  |  Submit date:2019/08/23
Proanthocyanidins in seed coat tegmen and endospermic cap inhibit seed germination in Sapium sebiferum 期刊论文
PEERJ, 2018, 卷号: 6, 期号: 无, 页码: 18
Authors:  Shah, Faheem Afzal;  Ni, Jun;  Chen, Jing;  Wang, Qiaojian;  Liu, Wenbo;  Chen, Xue;  Tang, Caiguo;  Fu, Songling;  Wu, Lifang
View  |  Adobe PDF(19708Kb)  |  Favorite  |  View/Download:4/1  |  Submit date:2019/06/04
Sapium sebiferum  Seed dormancy  Tegmen  Endospermic cap  Proanthocyanidins  ABA  GA  
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
Authors:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.;  Wang, Beilei;  Wang, Aoli;  Wang, Wei;  Chen, Cheng;  Liu, Xiaochuan;  Jiang, Zongru;  Hu, Zhenquan;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Qingsong;  Liu, Jing
View  |  Adobe PDF(5108Kb)  |  Favorite  |  View/Download:16/7  |  Submit date:2019/06/10
PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL  
N-(3-Oxo-acyl)-homoserine lactone induces apoptosis primarily through a mitochondrial pathway in fibroblasts 期刊论文
CELLULAR MICROBIOLOGY, 2018, 卷号: 20, 期号: 1, 页码: 15
Authors:  Neely, Aaron M.;  Zhao, Guoping;  Schwarzer, Christian;  Stivers, Nicole S.;  Whitt, Aaron G.;  Meng, Shuhan;  Burlison, Joseph A.;  Machen, Terry E.;  Li, Chi
View  |  Adobe PDF(4353Kb)  |  Favorite  |  View/Download:16/2  |  Submit date:2019/02/28
homoserine lactone  apoptosis  caspase  mitochondria  
Magnetic field direction differentially impacts the growth of different cell types 期刊论文
ELECTROMAGNETIC BIOLOGY AND MEDICINE, 2018, 卷号: 37, 期号: 2, 页码: 114-125
Authors:  Tian, Xiaofei;  Wang, Dongmei;  Zha, Meng;  Yang, Xingxing;  Ji, Xinmiao;  Zhang, Lei;  Zhang, Xin
View  |  Adobe PDF(2690Kb)  |  Favorite  |  View/Download:10/2  |  Submit date:2019/08/26
Magnetic resonance imaging (MRI)  static magnetic field (SMF)  magnetic field direction  cancer cells  non-cancer cells  
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway 期刊论文
NATURE COMMUNICATIONS, 2017, 卷号: 8, 期号: 无, 页码: 15
Authors:  Ma, Xiaoyu;  Wang, Lin;  Huang, De;  Li, Yunyan;  Yang, Dongdong;  Li, Tingting;  Li, Fudong;  Sun, Linchong;  Wei, Haoran;  He, Kun;  Yu, Fazhi;  Zhao, Debiao;  Hu, Lan;  Xing, Songge;  Liu, Zhaoji;  Li, Kui;  Guo, Jing;  Yang, Zhenye;  Pan, Xin;  Li, Ailing;  Shi, Yunyu;  Wang, Junfeng;  Gao, Ping;  Zhang, Huafeng
View  |  Adobe PDF(1933Kb)  |  Favorite  |  View/Download:10/5  |  Submit date:2019/02/28