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Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
Authors:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
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ABL kinase  Kinase inhibitor  ABL mutant  CML  
Targeting Nrf2-mediated heme oxygenase-1 enhances non-thermal plasma-induced cell death in non-small-cell lung cancer A549 cells 期刊论文
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2018, 卷号: 658, 页码: 54-65
Authors:  Ma, Jie;  Yu, K. N.;  Cheng, Cheng;  Ni, Guohua;  Shen, Jie;  Han, Wei
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Non-thermal plasma  Reactive oxygen species  Heme oxygenase-1  Apoptotic death  c-JUN N-terminal kinase  
N-acetylcysteine protects against microcystin-LR-induced endoplasmic reticulum stress and germ cell apoptosis in zebrafish testes 期刊论文
CHEMOSPHERE, 2018, 卷号: 204, 期号: 无, 页码: 463-473
Authors:  Zhao, Sujuan;  Liu, Ying;  Wang, Fang;  Xu, Dexiang;  Xie, Ping
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Microcystin  Endoplasmic reticulum stress  Apoptosis  N-acetylcysteine (NAC)  Zebrafish testes  
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627
Authors:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang;  Geng, Meiyu;  Ding, Jian;  Liu, Qingsong;  Sun, Liping;  Xie, Hua;  Zhang, Ao
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Proanthocyanidins in seed coat tegmen and endospermic cap inhibit seed germination in Sapium sebiferum 期刊论文
PEERJ, 2018, 卷号: 6, 期号: 无, 页码: 18
Authors:  Shah, Faheem Afzal;  Ni, Jun;  Chen, Jing;  Wang, Qiaojian;  Liu, Wenbo;  Chen, Xue;  Tang, Caiguo;  Fu, Songling;  Wu, Lifang
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Sapium sebiferum  Seed dormancy  Tegmen  Endospermic cap  Proanthocyanidins  ABA  GA  
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
Authors:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.;  Wang, Beilei;  Wang, Aoli;  Wang, Wei;  Chen, Cheng;  Liu, Xiaochuan;  Jiang, Zongru;  Hu, Zhenquan;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Qingsong;  Liu, Jing
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PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL  
Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy 期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 卷号: 546, 期号: 1-2, 页码: 215-225
Authors:  Li, Jun;  Liang, Huamin;  Liu, Jing;  Wang, Ziyuan
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N-(3-Oxo-acyl)-homoserine lactone induces apoptosis primarily through a mitochondrial pathway in fibroblasts 期刊论文
CELLULAR MICROBIOLOGY, 2018, 卷号: 20, 期号: 1, 页码: 15
Authors:  Neely, Aaron M.;  Zhao, Guoping;  Schwarzer, Christian;  Stivers, Nicole S.;  Whitt, Aaron G.;  Meng, Shuhan;  Burlison, Joseph A.;  Machen, Terry E.;  Li, Chi
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homoserine lactone  apoptosis  caspase  mitochondria  
Magnetic field direction differentially impacts the growth of different cell types 期刊论文
ELECTROMAGNETIC BIOLOGY AND MEDICINE, 2018, 卷号: 37, 期号: 2, 页码: 114-125
Authors:  Tian, Xiaofei;  Wang, Dongmei;  Zha, Meng;  Yang, Xingxing;  Ji, Xinmiao;  Zhang, Lei;  Zhang, Xin
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Magnetic resonance imaging (MRI)  static magnetic field (SMF)  magnetic field direction  cancer cells  non-cancer cells  
EFFECT OF MELATONIN ON NEURONAL DIFFERENTIATION REQUIRES CBP/P300-MEDIATED ACETYLATION OF HISTONE H3 LYSINE 14 期刊论文
NEUROSCIENCE, 2017, 卷号: 364, 期号: 无, 页码: 45-59
Authors:  Li, Xian;  Chen, Xueran;  Zhou, Wenjuan;  Ji, Shufang;  Li, Xinyue;  Li, Guanchong;  Liu, Guowei;  Wang, Fuwu;  Hao, Aijun
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melatonin  neural stem cells  neuronal differentiation  histone acetylation  histone H3 lysine 14  CREB-binding protein/p300