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Non-thermal plasma induces apoptosis accompanied by protective autophagy via activating JNK/Sestrin2 pathway 期刊论文
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2020, 卷号: 53
Authors:  Ma, Jie;  Yu, K. N.;  Zhang, Hao;  Nie, Lili;  Cheng, Cheng;  Cui, Shujun;  Yang, Miaomiao;  Chen, Guodong;  Han, Wei
Favorite  |  View/Download:49/0  |  Submit date:2020/10/28
non-thermal plasma  apoptosis  protective autophagy  c-JUN N-terminal kinase  Sestrin2  
The deep learning model combining CT image and clinicopathological information for predicting ALK fusion status and response to ALK-TKI therapy in non-small cell lung cancer patients 期刊论文
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2020
Authors:  Song, Zhengbo;  Liu, Tianchi;  Shi, Lei;  Yu, Zongyang;  Shen, Qing;  Xu, Mengdi;  Huang, Zhangzhou;  Cai, Zhijian;  Wang, Wenxian;  Xu, Chunwei;  Sun, Jingjing;  Chen, Ming
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Deep learning model  Anaplastic lymphoma kinase  Computed tomography  Non-small cell lung cancer  
Antagonizing CDK8 Sensitizes Colorectal Cancer to Radiation Through Potentiating the Transcription of e2f1 Target Gene apaf1 期刊论文
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 卷号: 8
Authors:  Chen, Bin;  Wen, Pengbo;  Hu, Guanshuo;  Gao, Yang;  Qi, Xiaojing;  Zhu, Kaili;  Chen, Shaopeng;  Wu, Lijun;  Xu, An;  Zhao, Guoping
Favorite  |  View/Download:1/0  |  Submit date:2020/10/21
CDK8  transcriptional regulation  e2f1  apaf1  radiotherapy  apoptosis  
Phosphorylation-Dependent SERS Readout for Activity Assay of Protein Kinase A in Cell Extracts 期刊论文
Nanomaterials, 2020
Authors:  Renyong Liu;  Chenggen Xie;  Yehan Yan;  Lin Hu;  Suhua Wang;  Khalid A. Alamry;  Hadi M. Marwani;  Lijuan Chen
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Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
Authors:  Wu, Jiaxin;  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Qi, Ziping;  Hu, Chen;  Wang, Wenliang;  Wu, Hong;  Huang, Tao;  Zhao, Ming;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Li, Lili;  Ge, Jian;  Ren, Tao;  Xia, Ruixiang;  Liu, Jing
Favorite  |  View/Download:11/0  |  Submit date:2019/11/27
BCR-ABL  PDGFR  chronic myeloid leukemia  kinase inhibitor  
Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of 期刊论文
J. Med. Chem., 2019
Authors:  Yun Wu;  Beilei Wang;  Junjie Wang;  Qi S(亓爽);  Fengming Zou;  Ziping Qi;  Feiyang Liu;  Wenchao Wang;  Qingsong Liu;  Jing Liu
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Nuclear factor (erythroid-derived 2)-like 2 antioxidative response mitigates cytoplasmic radiation-induced DNA double-strand breaks 期刊论文
CANCER SCIENCE, 2019, 卷号: 110, 期号: 2, 页码: 686-696
Authors:  Wang, Jun;  Konishi, Teruaki
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cytoplasm  double-strand DNA break  mitochondria  radiation biology  
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892
Authors:  Liang, Xiaofei;  Wang, Beilei;  Chen, Cheng;  Wang, Aoli;  Hu, Chen;  Zou, Fengming;  Yu, Kailin;  Liu, Qingwang;  Li, Feng;  Hu, Zhenquan;  Lu, Tingting;  Wang, Junjie;  Wang, Li;  Weisberg, Ellen L.;  Li, Lili;  Xia, Ruixiang;  Wang, Wenchao;  Ren, Tao;  Ge, Jian;  Liu, Jing;  Liu, Qinsong
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RNF12 catalyzes BRF1 ubiquitination and regulates RNA polymerase III-dependent transcription 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 1, 页码: 130-141
Authors:  Wang, Fang;  Zhao, Kailiang;  Yu, Sixiang;  Xu, An;  Han, Wei;  Mei, Yide
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RNA polymerase III  ubiquitin ligase  ubiquitylation (ubiquitination)  signal transduction  post-translational modification (PTM)  BRF1  RNF12  
Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 1, 页码: 52-64
Authors:  Deng, Ke;  Shen, Jiawei;  Wang, Wei;  Li, Ming;  Li, Hong;  Chen, Cheng;  Zhao, Huan;  Zhang, Mei;  Xue, Tian;  Liu, Qingsong;  Lui, Vivian Wai Yan;  Hong, Bo;  Lin, Wenchu
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small cell lung cancer  digoxin  NaCl  cardiac glycosides  ATP1A1