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Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
Authors:  Wu, Jiaxin;  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Qi, Ziping;  Hu, Chen;  Wang, Wenliang;  Wu, Hong;  Huang, Tao;  Zhao, Ming;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Li, Lili;  Ge, Jian;  Ren, Tao;  Xia, Ruixiang;  Liu, Jing
Favorite  |  View/Download:7/0  |  Submit date:2019/11/27
BCR-ABL  PDGFR  chronic myeloid leukemia  kinase inhibitor  
Preparation and characterization of temperature-triggered silica microcapsules containing sodium monofluorophosphate with tolerability to extreme pH 期刊论文
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2019, 卷号: 564, 期号: 无, 页码: 152-160
Authors:  Qu, Qiqi;  Wang, Hua;  He, Jing;  Su, Zheng;  Qin, Tengfei;  Tian, Xingyou
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W/O emulsion  Capsule  Sodium monofluorophosphate  
A novel wheel-confined composite as cathode in Li-S batteries with high capacity retention 期刊论文
JOURNAL OF ALLOYS AND COMPOUNDS, 2019, 卷号: 776, 期号: 无, 页码: 504-510
Authors:  Zhou, Ping;  Han, Tianli;  Gu, Cuiping;  Li, Jinjin;  Shen, Zihan;  Zhang, Huigang;  Niu, Junjie;  Liu, Jinhuai;  Liu, Jinyun
View  |  Adobe PDF(1706Kb)  |  Favorite  |  View/Download:5/1  |  Submit date:2020/03/31
Li-S battery  Composite  Low-temperature performance  Capacity stability  
Functional and structural characterization of a novel catechol-O-methyltransferase from Schizosaccharomyces pombe 期刊论文
IUBMB LIFE, 2019, 卷号: 71, 期号: 3, 页码: 330-339
Authors:  Wang, Qing;  Teng, Maikun;  Li, Xu
View  |  Adobe PDF(1895Kb)  |  Favorite  |  View/Download:2558/1075  |  Submit date:2020/05/21
catechol-O-methyltransferase  crystal structure  SAM-dependent  metal-dependent  Schizosaccharomyces pombe  
Nuclear factor (erythroid-derived 2)-like 2 antioxidative response mitigates cytoplasmic radiation-induced DNA double-strand breaks 期刊论文
CANCER SCIENCE, 2019, 卷号: 110, 期号: 2, 页码: 686-696
Authors:  Wang, Jun;  Konishi, Teruaki
View  |  Adobe PDF(913Kb)  |  Favorite  |  View/Download:2/0  |  Submit date:2020/05/21
cytoplasm  double-strand DNA break  mitochondria  radiation biology  
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892
Authors:  Liang, Xiaofei;  Wang, Beilei;  Chen, Cheng;  Wang, Aoli;  Hu, Chen;  Zou, Fengming;  Yu, Kailin;  Liu, Qingwang;  Li, Feng;  Hu, Zhenquan;  Lu, Tingting;  Wang, Junjie;  Wang, Li;  Weisberg, Ellen L.;  Li, Lili;  Xia, Ruixiang;  Wang, Wenchao;  Ren, Tao;  Ge, Jian;  Liu, Jing;  Liu, Qinsong
View  |  Adobe PDF(13868Kb)  |  Favorite  |  View/Download:144/142  |  Submit date:2020/05/21
RNF12 catalyzes BRF1 ubiquitination and regulates RNA polymerase III-dependent transcription 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 1, 页码: 130-141
Authors:  Wang, Fang;  Zhao, Kailiang;  Yu, Sixiang;  Xu, An;  Han, Wei;  Mei, Yide
View  |  Adobe PDF(8149Kb)  |  Favorite  |  View/Download:2/0  |  Submit date:2020/03/31
RNA polymerase III  ubiquitin ligase  ubiquitylation (ubiquitination)  signal transduction  post-translational modification (PTM)  BRF1  RNF12  
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
Authors:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  Favorite  |  View/Download:59/22  |  Submit date:2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Targeting Nrf2-mediated heme oxygenase-1 enhances non-thermal plasma-induced cell death in non-small-cell lung cancer A549 cells 期刊论文
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2018, 卷号: 658, 页码: 54-65
Authors:  Ma, Jie;  Yu, K. N.;  Cheng, Cheng;  Ni, Guohua;  Shen, Jie;  Han, Wei
Adobe PDF(4120Kb)  |  Favorite  |  View/Download:33/13  |  Submit date:2019/01/11
Non-thermal plasma  Reactive oxygen species  Heme oxygenase-1  Apoptotic death  c-JUN N-terminal kinase  
OsSND2, a NAC family transcription factor, is involved in secondary cell wall biosynthesis through regulating MYBs expression in rice 期刊论文
RICE, 2018, 卷号: 11, 期号: 无, 页码: 14
Authors:  Ye, Yafeng;  Wu, Kun;  Chen, Jianfeng;  Liu, Qian;  Wu, Yuejin;  Liu, Binmei;  Fu, Xiangdong
View  |  Adobe PDF(4528Kb)  |  Favorite  |  View/Download:6/0  |  Submit date:2019/08/23
Secondary cell wall (SCW)  Rice  Cellulose synthesis  Transcription factor (TF)  NAC  MYB