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Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
Authors:  Wu, Jiaxin;  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Qi, Ziping;  Hu, Chen;  Wang, Wenliang;  Wu, Hong;  Huang, Tao;  Zhao, Ming;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Li, Lili;  Ge, Jian;  Ren, Tao;  Xia, Ruixiang;  Liu, Jing
Favorite  |  View/Download:3/0  |  Submit date:2019/11/27
BCR-ABL  PDGFR  chronic myeloid leukemia  kinase inhibitor  
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
Authors:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  Favorite  |  View/Download:55/20  |  Submit date:2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Targeting Nrf2-mediated heme oxygenase-1 enhances non-thermal plasma-induced cell death in non-small-cell lung cancer A549 cells 期刊论文
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2018, 卷号: 658, 页码: 54-65
Authors:  Ma, Jie;  Yu, K. N.;  Cheng, Cheng;  Ni, Guohua;  Shen, Jie;  Han, Wei
Adobe PDF(4120Kb)  |  Favorite  |  View/Download:25/9  |  Submit date:2019/01/11
Non-thermal plasma  Reactive oxygen species  Heme oxygenase-1  Apoptotic death  c-JUN N-terminal kinase  
OsSND2, a NAC family transcription factor, is involved in secondary cell wall biosynthesis through regulating MYBs expression in rice 期刊论文
RICE, 2018, 卷号: 11, 期号: 无, 页码: 14
Authors:  Ye, Yafeng;  Wu, Kun;  Chen, Jianfeng;  Liu, Qian;  Wu, Yuejin;  Liu, Binmei;  Fu, Xiangdong
View  |  Adobe PDF(4528Kb)  |  Favorite  |  View/Download:4/0  |  Submit date:2019/08/23
Secondary cell wall (SCW)  Rice  Cellulose synthesis  Transcription factor (TF)  NAC  MYB  
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627
Authors:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang;  Geng, Meiyu;  Ding, Jian;  Liu, Qingsong;  Sun, Liping;  Xie, Hua;  Zhang, Ao
View  |  Adobe PDF(6587Kb)  |  Favorite  |  View/Download:97/92  |  Submit date:2019/08/23
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
Authors:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.;  Wang, Beilei;  Wang, Aoli;  Wang, Wei;  Chen, Cheng;  Liu, Xiaochuan;  Jiang, Zongru;  Hu, Zhenquan;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Qingsong;  Liu, Jing
View  |  Adobe PDF(5108Kb)  |  Favorite  |  View/Download:17/7  |  Submit date:2019/06/10
PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL  
Cross-Platform Cancer Cell Identification Using Telomerase-Specific Spherical Nucleic Acids 期刊论文
ACS NANO, 2018, 卷号: 12, 期号: 4, 页码: 3629-3637
Authors:  Liu, Zhengjie;  Zhao, Jun;  Zhang, Ruilong;  Han, Guangmei;  Zhang, Cheng;  Liu, Bianhua;  Zhang, Zhongping;  Han, Ming-Yong;  Gao, Xiaohu
View  |  Adobe PDF(1607Kb)  |  Favorite  |  View/Download:5/1  |  Submit date:2019/08/23
telomerase  spherical nucleic acids  cancer  molecular beacons  surgery navigation  imaging  detection  
N-(3-Oxo-acyl)-homoserine lactone induces apoptosis primarily through a mitochondrial pathway in fibroblasts 期刊论文
CELLULAR MICROBIOLOGY, 2018, 卷号: 20, 期号: 1, 页码: 15
Authors:  Neely, Aaron M.;  Zhao, Guoping;  Schwarzer, Christian;  Stivers, Nicole S.;  Whitt, Aaron G.;  Meng, Shuhan;  Burlison, Joseph A.;  Machen, Terry E.;  Li, Chi
View  |  Adobe PDF(4353Kb)  |  Favorite  |  View/Download:17/2  |  Submit date:2019/02/28
homoserine lactone  apoptosis  caspase  mitochondria  
Phytoplankton photosynthetic rate measurement using tunable pulsed light induced fluorescence kinetics 期刊论文
OPTICS EXPRESS, 2018, 卷号: 26, 期号: 6, 页码: A293-A300
Authors:  GAOFANG YIN;  CHAOYI SHI;  SHUANG CHEN;  ZHISONG QIN;  XIAOLING ZHANG;  RUIFANG YAN;  TINGTING GAN;  JIANGUO LIU;  WENQING LIU
View  |  Adobe PDF(2082Kb)  |  Favorite  |  View/Download:16/4  |  Submit date:2018/10/17
Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy 期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 卷号: 546, 期号: 1-2, 页码: 215-225
Authors:  Li, Jun;  Liang, Huamin;  Liu, Jing;  Wang, Ziyuan
View  |  Adobe PDF(3199Kb)  |  Favorite  |  View/Download:69/51  |  Submit date:2018/10/10