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Aberrant copper metabolism and hepatic inflammation cause neurological manifestations in a mouse model of Wilson's disease 期刊论文
JOURNAL OF NEUROINFLAMMATION, 2024, 卷号: 21
Authors:  Dong, Jianjian;  Xiang, Guanghai;  Xia, Xiaoxue;  Xu, Lewen;  Wen, Peihua;  Xu, Chenchen;  Xu, Yin;  Su, Yushuang;  Song, Yanze;  Tong, Haiyang;  Zhu, Qingjun;  Han, Yongzhu;  Han, Yongsheng;  Cheng, Nan;  Wang, Haoyi;  Zhou, Hong
Favorite  |  View/Download:2/0  |  Submit date:2024/11/20
Wilson's disease  ATP7B gene  R778L point mutation  Hepatic inflammation  Neurological manifestations  CRISPR/Cas9  
A novel PDGFR inhibitor WQ-C-401 prevents pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension 期刊论文
EXPERIMENTAL CELL RESEARCH, 2024, 卷号: 441
Authors:  Huang, Wen;  Zhou, Hong;  He, Yiting;  Wang, Aoli;  Wang, Beilei;  Chen, Yongfei;  Liu, Chenyang;  Wang, Hong;  Xie, Weiping;  Kong, Hui
Favorite  |  View/Download:2/0  |  Submit date:2024/11/22
WQ-C-401  Pulmonary arterial hypertension  Pulmonary vascular remodeling  Platelet-derived growth factor receptor  Smooth muscle cells  
Sevoflurane enhances autophagy via Rac1 to attenuate lung ischaemia-reperfusion injury 期刊论文
CHEMICO-BIOLOGICAL INTERACTIONS, 2024, 卷号: 397
Authors:  Ding, Xian;  Gao, Xiang;  Ren, Aolin;  Xu, Jingjing;  Jiang, Xuliang;  Liang, Xiao;  Xie, Kangjie;  Zhou, Yan;  Hu, Chunxiao;  Huang, Dongxiao
Favorite  |  View/Download:1/0  |  Submit date:2024/11/20
Lung ischaemia-reperfusion injury  Sevoflurane  Rac1  Autophagy  
Daqing formula ameliorated allergic asthma and airway dysbacteriosis in mice challenged with ovalbumin and ampicillin 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2024, 卷号: 318
Authors:  Wu, Li-ren;  Peng, Qian-Yu;  Li, Xue-Jian;  Guo, Mei-Ying;  He, Jia-Qi;  Ying, Hua-Zhong;  Yu, Chen-Huan
Favorite  |  View/Download:39/0  |  Submit date:2023/11/10
Lung dysbiosis  Th1/Th2 balance  Antibiotic  GSK-3 ss  
E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2 期刊论文
EMBO REPORTS, 2022
Authors:  Li, Hui;  Wang, Ning;  Jiang, Yu;  Wang, Haofei;  Xin, Zengfeng;  An, Huazhang;  Pan, Hao;  Ma, Wangqian;  Zhang, Ting;  Wang, Xiaojian;  Lin, Wenlong
Favorite  |  View/Download:45/0  |  Submit date:2022/12/22
IL-17R signaling  inflammation  MEKK2  NEDD4L  ubiquitination  
3,3 '-Diindolylmethane attenuates inflammation and fibrosis in radiation-induced lung injury by regulating NF-kappa B/TGF-beta/Smad signaling pathways 期刊论文
EXPERIMENTAL LUNG RESEARCH, 2022, 卷号: 48
Authors:  Zhou, Xia;  Bao, Wu-An;  Zhu, Xiang;  Lin, Juan;  Fan, Ju-Fen;  Yang, Yang;  Du, Xiang-Hui;  Wang, Yue-Zhen
Favorite  |  View/Download:42/0  |  Submit date:2022/12/23
3,3 '-Diindolylmethane  inflammatory  NF-kappa B  pulmonary fibrosis  radiation-induced lung injury  TGF beta/Smad pathway  
The Modulation of Chaihu Shugan Formula on Microbiota Composition in the Simulator of the Human Intestinal Microbial Ecosystem Technology Platform and its Influence on Gut Barrier and Intestinal Immunity in Caco-2/THP1-Blue (TM) Cell Co-Culture Model 期刊论文
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13
Authors:  Liu, Ling;  Lu, Yi;  Xu, Chao;  Chen, Haitao;  Wang, Xuanying;  Wang, Yijie;  Cai, Biyu;  Li, Bing;  Verstrepen, Lynn;  Ghyselinck, Jonas;  Marzorati, Massimo;  Yao, Qinghua
Favorite  |  View/Download:52/0  |  Submit date:2022/05/16
chaihu shugan formula  gut microbiota  gut barrier  intestinal immunity  SHIMS (R) platform  human  
HMGB1 augments cognitive impairment in sepsis-associated encephalopathy by binding to MD-2 and promoting NLRP3-induced neuroinflammation 期刊论文
PSYCHOGERIATRICS, 2021
Authors:  Xiong, Yanan;  Yang, Jilin;  Tong, Haiyang;  Zhu, Chenting;  Pang, Yinhu
Favorite  |  View/Download:60/0  |  Submit date:2022/01/25
cognitive impairment  HMGB1  MD-2  neuroinflammation  NLRP3  sepsis-associated encephalopathy  
Caspase-3-mediated GSDME induced Pyroptosis in breast cancer cells through the ROS/JNK signalling pathway 期刊论文
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2021
Authors:  Zhang, Ziwen;  Zhang, Han;  Li, Dongbo;  Zhou, Xiaoping;  Qin, Qi;  Zhang, Qingyuan
Favorite  |  View/Download:60/0  |  Submit date:2021/09/06
breast cancer  doxorubicin  GSDME  pyroptosis  ROS  JNK pathway  
Inhibiting NLRP3 inflammasome activation prevents copper-induced neuropathology in a murine model of Wilson's disease 期刊论文
CELL DEATH & DISEASE, 2021, 卷号: 12
Authors:  Dong, Jianjian;  Wang, Xun;  Xu, Chenchen;  Gao, Manli;  Wang, Shijing;  Zhang, Jin;  Tong, Haiyang;  Wang, Lulu;  Han, Yongzhu;  Cheng, Nan;  Han, Yongsheng
Favorite  |  View/Download:103/0  |  Submit date:2021/03/15