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HFCAS OpenIR

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Gefitinib enhances the anti-tumor immune response against EGFR-mutated NSCLC by upregulating B7H5 expression and activating T cells via CD28H 期刊论文
INTERNATIONAL JOURNAL OF ONCOLOGY, 2022, 卷号: 61
作者:  Guo, Huihui;  Zhang, Xilin;  Xie, Shangzhi;  Chen, Tianwei;  Xie, Dong;  Cai, Ying;  Cui, Dawei;  Wang, Liang;  Chen, Wei;  Wang, Xiang
收藏  |  浏览/下载：29/0  |  提交时间：2022/12/22
gefitinib  CD28H  NSCLC  EGFR mutation  
The effect of EGFR-TKIs on survival in advanced non-small-cell lung cancer with EGFR mutations: A real-world study 期刊论文
CANCER MEDICINE, 2022
作者:  Yu, Xiaoqing;  Si, Jinfei;  Wei, Jingwen;  Wang, Yanling;  Sun, Yan;  Jin, Jianan;  Zhang, Xiaoyan;  Ma, Tonghui;  Song, Zhengbo
收藏  |  浏览/下载：40/0  |  提交时间：2022/12/23
EGFR-TKIs  non-small cell lung cancer (NSCLC)  real-world study  survival outcome  
Impact of clinical and molecular features on efficacy and outcome of patients with non-small cell lung cancer receiving second-line osimertinib 期刊论文
BMC CANCER, 2022, 卷号: 22
作者:  Jin, Ying;  Lin, Chen;  Shi, Xun;  He, Qiong;  Yan, Junrong;  Yu, Xinmin;  Chen, Ming
收藏  |  浏览/下载：30/0  |  提交时间：2022/12/23
Clinical and molecular features  Efficacy and outcome  EGFR T790M mutation  Non-small-cell lung cancer  Osimertinib  
Efficacy and safety of anlotinib with and without EGFR-TKIs or immunotherapy in the treatment of elder patients with non-small-cell lung cancer: a retrospective study 期刊论文
BMC PULMONARY MEDICINE, 2022, 卷号: 22
作者:  Wang, Wenxian;  Shao, Lan;  Xu, Yibing;  Song, Zhengbo;  Lou, Guangyuan;  Zhang, Yiping;  Chen, Ming
收藏  |  浏览/下载：24/0  |  提交时间：2022/12/23
Non-small cell lung cancer  Prognosis  Angiogenesis  Tyrosine kinase inhibitors  
Clinical outcomes of lung adenocarcinoma patients harboring uncommon epidermal growth factor receptor (EGFR) mutations treated with EGFR-tyrosine kinase inhibitors (TKIs) 期刊论文
ANNALS OF PALLIATIVE MEDICINE, 2021
作者:  Si, Jinfei;  Gu, Xiaodong;  Wang, Wenxian;  Ying, Shenpeng;  Song, Zhengbo
收藏  |  浏览/下载：89/0  |  提交时间：2022/02/14
Epidermal growth factor receptor (EGFR)  uncommon mutation  compound mutation  double uncommon mutation  lung adenocarcinoma (lung AC)  
The correlation between the abundance of EGFR T790M mutation and osimertinib response in advanced non-small cell lung cancer 期刊论文
TRANSLATIONAL CANCER RESEARCH, 2021, 卷号: 10
作者:  Pan, Guoqiang;  Chen, Kaiyan;  Yu, Xiaoqing;  Sheng, Jiamin;  Fan, Yun
收藏  |  浏览/下载：42/0  |  提交时间：2021/11/01
Non-small cell lung cancer (NSCLC)  T790M abundance  droplet digital PCR (ddPCR)  next generation sequencing (NGS)  osimertinib  
The genomic landscape of young and old lung cancer patients highlights age-dependent mutation frequencies and clinical actionability in young patients 期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2021
作者:  Cai, Lei;  Chen, Yong;  Tong, Xiaoling;  Wu, Xue;  Bao, Hua;  Shao, Yang;  Luo, Zhuang;  Wang, Xuming;  Cao, Yang
收藏  |  浏览/下载：71/0  |  提交时间：2021/06/15
EGFR  ERBB2  gene fusions  tyrosine kinase inhibitors  young lung cancer patients  
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21274/11466  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:  Wang, Aoli;  Li, Xixiang;  Wu, Hong;  Zou, Fengming;  Yan, Xiao-E;  Chen, Cheng;  Hu, Chen;  Yu, Kailin;  Wang, Wenchao;  Zhao, Peng;  Wu, Jiaxin;  Qi, Ziping;  Wang, Wei;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：27/0  |  提交时间：2018/07/26
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:  Wang, Aoli;  Li, Xixiang;  Wu, Hong;  Zou, Fengming;  Yan, Xiao-E;  Chen, Cheng;  Hu, Chen;  Yu, Kailin;  Wang, Wenchao;  Zhao, Peng;  Wu, Jiaxin;  Qi, Ziping;  Wang, Wei;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：47/0  |  提交时间：2018/07/26