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Discovery of N-((1-(4-(3-(3-((6,7-Dimethoxyquinolin-3-yl)oxy)phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)methyl)propionamide (CHMFL-KIT-8140) as a Highly Potent Type II Inhibitor Capable of Inhibiting the T670I "Gatekeeper" Mutant of cKIT Kinase 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 18, 页码: 8456-8472
Authors:  Li, Binhua;  Wang, Aoli;  Liu, Juan;  Qi, Ziping;  Liu, Xiaochuan;  Yu, Kailin;  Wu, Hong;  Chen, Cheng;  Hu, Chen;  Wang, Wenchao;  Wu, Jiaxin;  Hu, Zhenquan;  Ye, Ling;  Zou, Fengming;  Liu, Feiyang;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shaojuan;  Bai, Mingfeng;  Zhang, Shanchun;  Liu, Jing;  Liu, Qingsong
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Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML) 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 29, 页码: 45562-45574
Authors:  Liu, Feiyang;  Wang, Beilei;  Wang, Qiang;  Qi, Ziping;  Chen, Cheng;  Kong, Lu-Lu;  Chen, Ji-Yun;  Liu, Xiaochuan;  Wang, Aoli;  Hu, Chen;  Wang, Wenchao;  Wang, Huiping;  Wu, Fan;  Ruan, Yanjie;  Qi, Shuang;  Liu, Juan;  Zou, Fengming;  Hu, Zhenquan;  Wang, Wei;  Wang, Li;  Zhang, Shanchun;  Yun, Cai-Hong;  Zhai, Zhimin;  Liu, Jing;  Liu, Qingsong
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Bcr-abl  Pdgfr  Chronic Myeloid Leukemia  Kinase Inhibitor  
Dual Inhibition of AKT/FLT3-ITD by A674563 Overcomes FLT3 Ligand-Induced Drug Resistance in FLT3-ITD positive AML 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 20, 页码: 29131-29142
Authors:  Wang, Aoli;  Wu, Hong;  Chen, Cheng;  Hu, Chen;  Qi, Ziping;  Wang, Wenchao;  Yu, Kailin;  Liu, Xiaochuan;  Zou, Fengming;  Zhao, Zheng;  Wu, Jiaxin;  Liu, Juan;  Liu, Feiyang;  Wang, Li;  Stone, Richard M.;  Galinksy, Ilene A.;  Griffin, James D.;  Zhang, Shanchun;  Weisberg, Ellen L.;  Liu, Jing;  Liu, Qingsong
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Acute Myeloid Leukemia  Flt3-itd  Akt  A6745763  Flt3-ligand  
Discovery of N-(34(1-lsonicotinoylpiperidin-4-yl)oxy)-4methylpheny1)-3-(trifluoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c-KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs) 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 8, 页码: 3964-3979
Authors:  Wang, Qang;  Liu, Feiyang;  Wang, Beilei;  Zou, Fengming;  Chen, Cheng;  Liu, Xiaochuan;  Wang, Aoli;  Qi, Shuang;  Wang, Wenchao;  Qi, Ziping;  Zhao, Zheng;  Hu, Zhenquan;  Wang, Wei;  Wang, Li;  Zhang, Shanchun;  Wang, Yuexiang;  Liu, Jing;  Liu, Qingsong
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Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 5, 页码: 1984-2004
Authors:  Liang, Xiaofei;  Liu, Xiaochuan;  Wang, Beilei;  Zou, Fengming;  Wang, Aoli;  Qi, Shuan;  Chen, Cheng;  Zhao, Zheng;  Wang, Wenchao;  Qi, Ziping;  Lv, Fengchao;  Hu, Zhenquan;  Wang, Li;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
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Ibrutinib selectively targets FLT3-ITD in mutant FLT3-positive AML 期刊论文
LEUKEMIA, 2016, 卷号: 30, 期号: 3, 页码: 754-757
Authors:  Wu, H.;  Hu, C.;  Wang, A.;  Weisberg, E. L.;  Wang, W.;  Chen, C.;  Zhao, Z.;  Yu, K.;  Liu, J.;  Wu, J.;  Nonami, A.;  Wang, L.;  Wang, B.;  Stone, R. M.;  Liu, S.;  Griffin, J. D.;  Liu, J.;  Liu, Q.
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c-Abl-p38 alpha signaling plays an important role in MPTP-induced neuronal death 期刊论文
CELL DEATH AND DIFFERENTIATION, 2016, 卷号: 23, 期号: 2, 页码: 542-552
Authors:  Wu, R.;  Chen, H.;  Ma, J.;  He, Q.;  Huang, Q.;  Liu, Q.;  Li, M.;  Yuan, Z.
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Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia 期刊论文
LEUKEMIA, 2016, 卷号: 30, 期号: 1, 页码: 173-181
Authors:  Wu, H.;  Hu, C.;  Wang, A.;  Weisberg, E. L.;  Chen, Y.;  Yun, C-H;  Wang, W.;  Liu, Y.;  Liu, X.;  Tian, B.;  Wang, J.;  Zhao, Z.;  Liang, Y.;  Li, B.;  Wang, L.;  Wang, B.;  Chen, C.;  Buhrlage, S. J.;  Qi, Z.;  Zou, F.;  Nonami, A.;  Li, Y.;  Fernandes, S. M.;  Adamia, S.;  Stone, R. M.;  Galinsky, I. A.;  Wang, X.;  Yang, G.;  Griffin, J. D.;  Brown, J. R.;  Eck, M. J.;  Liu, J.;  Gray, N. S.;  Liu, Q.
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