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Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 1, 页码: 52-64
作者:  Deng, Ke;  Shen, Jiawei;  Wang, Wei;  Li, Ming;  Li, Hong;  Chen, Cheng;  Zhao, Huan;  Zhang, Mei;  Xue, Tian;  Liu, Qingsong;  Lui, Vivian Wai Yan;  Hong, Bo;  Lin, Wenchu
浏览  |  Adobe PDF(3554Kb)  |  收藏  |  浏览/下载：67/27  |  提交时间：2020/03/31
small cell lung cancer  digoxin  NaCl  cardiac glycosides  ATP1A1  
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627
作者:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang;  Geng, Meiyu;  Ding, Jian;  Liu, Qingsong;  Sun, Liping;  Xie, Hua;  Zhang, Ao
浏览  |  Adobe PDF(6587Kb)  |  收藏  |  浏览/下载：147/106  |  提交时间：2019/08/23
Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders 期刊论文
JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 卷号: 214, 期号: 11, 页码: 3219-3238
作者:  Jiang, Hua;  He, Hongbin;  Chen, Yun;  Huang, Wei;  Cheng, Jinbo;  Ye, Jin;  Wang, Aoli;  Tao, Jinhui;  Wang, Chao;  Liu, Qingsong;  Jin, Tengchuan;  Jiang, Wei;  Deng, Xianming;  Zhou, Rongbin
浏览  |  Adobe PDF(2740Kb)  |  收藏  |  浏览/下载：221/155  |  提交时间：2019/06/17
Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: 无, 页码: 1-10
作者:  Wu, Hong;  Huang, Qiong;  Qi, Ziping;  Chen, Yongfei;  Wang, Aoli;  Chen, Cheng;  Liang, Qianmao;  Wang, Jinghua;  Chen, Wensheng;  Dong, Jin;  Yu, Kailin;  Hu, Chen;  Wang, Wenchao;  Liu, Xiaochuan;  Deng, Yuanxin;  Wang, Li;  Wang, Beilei;  Li, Xiaoxiang;  Gray, Nathanael S.;  Liu, Jing;  Wei, Wei;  Liu, Qingsong
浏览  |  Adobe PDF(3966Kb)  |  收藏  |  浏览/下载：121/63  |  提交时间：2018/07/04
STK16 regulates actin dynamics to control Golgi organization and cell cycle 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: 无, 页码: 1-17
作者:  Liu, Juanjuan;  Yang, Xingxing;  Li, Binhua;  Wang, Junjun;  Wang, Wenchao;  Liu, Jing;  Liu, Qingsong;  Zhang, Xin
浏览  |  Adobe PDF(3465Kb)  |  收藏  |  浏览/下载：95/47  |  提交时间：2018/07/04
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxybenzamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 1793-1816
作者:  Liang, Xiaofei;  Lv, Fengchao;  Wang, Beilei;  Yu, Kailin;  Wu, Hong;  Qi, Ziping;  Jiang, Zongru;  Chen, Cheng;  Wang, Aoli;  Miao, Weili;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Liu, Xiaochuan;  Zhao, Zheng;  Wang, Li;  Zhang, Shanchuan;  Ye, Zi;  Wang, Chu;  Ren, Tao;  Wang, Yinsheng;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5919Kb)  |  收藏  |  浏览/下载：17293/7523  |  提交时间：2018/07/04
Discovery of 4-Methyl-N-(44(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-y1)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge Binding 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 1, 页码: 273-289
作者:  Wang, Qiang;  Liu, Feiyang;  Wang, Beilei;  Zou, Fengming;  Qi, Ziping;  Chen, Cheng;  Yu, Kailin;  Hu, Chen;  Qi, Shuang;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Wang, Wei;  Wang, Li;  Liang, Qianmao;  Zhang, Shanchun;  Ren, Tao;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(3516Kb)  |  收藏  |  浏览/下载：99/57  |  提交时间：2018/07/04
Rutin ameliorates obesity through brown fat activation 期刊论文
FASEB JOURNAL, 2017, 卷号: 31, 期号: 1, 页码: 333-+
作者:  Yuan, Xiaoxue;  Wei, Gang;  You, Yilin;  Huang, Yuanyuan;  Lee, Hyuek Jong;  Dong, Meng;  Lin, Jun;  Hu, Tao;  Zhang, Hanlin;  Zhang, Chuanhai;  Zhou, Huiqiao;  Ye, Rongcai;  Qi, Xiaolong;  Zhai, Baiqiang;  Huang, Weidong;  Liu, Shunai;  Xie, Wen;  Liu, Qingsong;  Liu, Xiaomeng;  Cui, Chengbi;  Li, Donghao;  Zhan, Jicheng;  Cheng, Jun;  Yuan, Zengqiang;  Jin, Wanzhu
浏览  |  Adobe PDF(2063Kb)  |  收藏  |  浏览/下载：147/43  |  提交时间：2018/07/04
Brown Adipose Tissue  Rutin  Obesity  Energy Expenditure  Mitochondria  
Sub-molecular features of single proteins in solution resolved with scanning tunneling microscopy 期刊论文
NANO RESEARCH, 2016, 卷号: 9, 期号: 9, 页码: 2551-2560
作者:  Wang, Jihao;  Zhang, Lei;  Hu, Chen;  Liu, Qingsong;  Hou, Yubin;  Zhang, Xin;  Lu, Qingyou
浏览  |  Adobe PDF(1895Kb)  |  收藏  |  浏览/下载：77/39  |  提交时间：2017/11/21
Liquid-phase Scanning Tunneling Microscopy (Stm)  Stm Imaging Under Physiological Conditions  Protein Molecule  Sub-molecular Resolution  
Simultaneous inhibition of Vps34 kinase would enhance PI3K delta inhibitor cytotoxicity in the B-cell malignancies 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 33, 页码: 53515-53525
作者:  Liu, Xiaochuan;  Wang, Aoli;  Liang, Xiaofei;  Liu, Juanjuan;  Zou, Fengming;  Chen, Cheng;  Zhao, Zheng;  Deng, Yuanxin;  Wu, Hong;  Qi, Ziping;  Wang, Beilei;  Wang, Li;  Liu, Feiyang;  Xu, Yunhe;  Wang, Wenchao;  Fernandes, Stacey M.;  Stone, Richard M.;  Galinsky, Ilene A.;  Brown, Jennifer R.;  Loh, Teckpeng;  Griffin, James. D.;  Zhang, Shanchun;  Weisberg, Ellen L.;  Zhang, Xin;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(7625Kb)  |  收藏  |  浏览/下载：95/37  |  提交时间：2017/11/21
Pi3k Delta  Vps34  Combination  Chronic Lymphatic Leukemia  Acute Myeloid Leukemia