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Discovery of N-((1-(4-(3-(3-((6,7-Dimethoxyquinolin-3-yl)oxy)phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)methyl)propionamide (CHMFL-KIT-8140) as a Highly Potent Type II Inhibitor Capable of Inhibiting the T670I "Gatekeeper" Mutant of cKIT Kinase 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 18, 页码: 8456-8472
作者:  Li, Binhua;  Wang, Aoli;  Liu, Juan;  Qi, Ziping;  Liu, Xiaochuan;  Yu, Kailin;  Wu, Hong;  Chen, Cheng;  Hu, Chen;  Wang, Wenchao;  Wu, Jiaxin;  Hu, Zhenquan;  Ye, Ling;  Zou, Fengming;  Liu, Feiyang;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shaojuan;  Bai, Mingfeng;  Zhang, Shanchun;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(2856Kb)  |  收藏  |  浏览/下载：1401/1298  |  提交时间：2017/11/21
Discovery of N-(34(1-lsonicotinoylpiperidin-4-yl)oxy)-4methylpheny1)-3-(trifluoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c-KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs) 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 8, 页码: 3964-3979
作者:  Wang, Qang;  Liu, Feiyang;  Wang, Beilei;  Zou, Fengming;  Chen, Cheng;  Liu, Xiaochuan;  Wang, Aoli;  Qi, Shuang;  Wang, Wenchao;  Qi, Ziping;  Zhao, Zheng;  Hu, Zhenquan;  Wang, Wei;  Wang, Li;  Zhang, Shanchun;  Wang, Yuexiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10221Kb)  |  收藏  |  浏览/下载：123/72  |  提交时间：2017/11/10
Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 5, 页码: 1984-2004
作者:  Liang, Xiaofei;  Liu, Xiaochuan;  Wang, Beilei;  Zou, Fengming;  Wang, Aoli;  Qi, Shuan;  Chen, Cheng;  Zhao, Zheng;  Wang, Wenchao;  Qi, Ziping;  Lv, Fengchao;  Hu, Zhenquan;  Wang, Li;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(3635Kb)  |  收藏  |  浏览/下载：13701/5311  |  提交时间：2017/11/06