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HFCAS OpenIR
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Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  收藏  |  浏览/下载：187/104  |  提交时间：2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21274/11466  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxybenzamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 1793-1816
作者:  Liang, Xiaofei;  Lv, Fengchao;  Wang, Beilei;  Yu, Kailin;  Wu, Hong;  Qi, Ziping;  Jiang, Zongru;  Chen, Cheng;  Wang, Aoli;  Miao, Weili;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Liu, Xiaochuan;  Zhao, Zheng;  Wang, Li;  Zhang, Shanchuan;  Ye, Zi;  Wang, Chu;  Ren, Tao;  Wang, Yinsheng;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5919Kb)  |  收藏  |  浏览/下载：17292/7523  |  提交时间：2018/07/04
Dual Inhibition of AKT/FLT3-ITD by A674563 Overcomes FLT3 Ligand-Induced Drug Resistance in FLT3-ITD positive AML 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 20, 页码: 29131-29142
作者:  Wang, Aoli;  Wu, Hong;  Chen, Cheng;  Hu, Chen;  Qi, Ziping;  Wang, Wenchao;  Yu, Kailin;  Liu, Xiaochuan;  Zou, Fengming;  Zhao, Zheng;  Wu, Jiaxin;  Liu, Juan;  Liu, Feiyang;  Wang, Li;  Stone, Richard M.;  Galinksy, Ilene A.;  Griffin, James D.;  Zhang, Shanchun;  Weisberg, Ellen L.;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(4786Kb)  |  收藏  |  浏览/下载：131/35  |  提交时间：2017/11/16
Acute Myeloid Leukemia  Flt3-itd  Akt  A6745763  Flt3-ligand  
针对B细胞相关肿瘤的新型靶向药物研究 学位论文
, 合肥: 中国科学技术大学, 2016
作者:  吴宏
Adobe PDF(5488Kb)  |  收藏  |  浏览/下载：21/1  |  提交时间：2018/01/18
Discovery of (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 58, 期号: 24, 页码: 9625-9638
作者:  Li, Xixiang;  Wang, Aoli;  Yu, Kailin;  Qi, Ziping;  Chen, Cheng;  Wang, Wenchao;  Hu, Chen;  Wu, Hong;  Wu, Jiaxin;  Zhao, Zheng;  Liu, Juan;  Zou, Fengming;  Wang, Li;  Wang, Beilei;  Wang, Wei;  Zhang, Shanchun;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(6123Kb)  |  收藏  |  浏览/下载：158/100  |  提交时间：2017/10/25
Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma 期刊论文
ACS Chem. Biol, 2014, 卷号: 9, 期号: 5, 页码: 1086-1091
作者:  Hong Wu;  Wenchao Wang;  Feiyang Liu;  Yongfei Chen;  Binhua Li;  Aoli Wang;  Beilei Wang;  Zheng Zhao;  Chen Hu;  Hong Li;  Jing Liu;  Qingsong Liu等
浏览  |  Adobe PDF(2079Kb)  |  收藏  |  浏览/下载：38/24  |  提交时间：2016/11/22