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Efficacy of afatinib, an irreversible ErbB family blocker, in the treatment of intracerebral metastases of non-small cell lung cancer in mice 期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38
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BRAIN METASTASES  CEREBROSPINAL-FLUID  GEFITINIB  INHIBITORS  CARCINOMA  RADIATION  ERLOTINIB  afatinib  tyrosine kinase inhibitor  non-small cell lung cancer  brain metastasis  pharmacokinetic/pharmacodynamics  pEGFR  
Efficacy and safety of icotinib in Chinese patients with advanced non-small cell lung cancer after failure of chemotherapy 期刊论文
CHINESE MEDICAL JOURNAL, 2014, 卷号: 127
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PREVIOUSLY TREATED PATIENTS  TYROSINE KINASE INHIBITORS  FACTOR RECEPTOR MUTATIONS  SKIN RASH  ERLOTINIB EFFICACY  GEFITINIB  EGFR  TRIAL  BENEFIT  ADENOCARCINOMA  non-small cell lung cancer  icotinib  antitumor activity  adverse events  
The crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor 期刊论文
JOURNAL OF MOLECULAR CELL BIOLOGY, 2012, 卷号: 4
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KINASE KINASE-1/2 INHIBITOR  PHOSPHOINOSITIDE 3-KINASE-GAMMA  ADVANCED CANCERS  LUNG-CANCER  CELL LUNG  PHASE-II  RESISTANCE  ROBUSTNESS  ACTIVATION  MUTATIONS  systems biology  mathematical model  ERK pathway  PI3K pathway  MEK inhibitor  resistance  robustness  biochemical control analysis