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Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway 期刊论文
Nature Communications, 2017
作者:  Ma, Xiaoyu;  Wang, Lin;  Huang, De;  Li, Yunyan;  Yang, Dongdong;  Li, Tingting;  Li, Fudong;  Sun, Linchong;  Wei, Haoran;  He, Kun;  Yu, Fazhi;  Zhao, Debiao;  Hu, Lan;  Xing, Songge;  Liu, Zhaoji;  Li, Kui;  Guo, Jing;  Yang, Zhenye;  Pan, Xin;  Li, Ailing;  Shi, Yunyu;  Wang, Junfeng;  Gao, Ping;  Zhang, Huafeng
浏览  |  Adobe PDF(1933Kb)  |  收藏  |  浏览/下载：79/37  |  提交时间：2020/10/22
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway 期刊论文
NATURE COMMUNICATIONS, 2017, 卷号: 8, 期号: 无, 页码: 15
作者:  Ma, Xiaoyu;  Wang, Lin;  Huang, De;  Li, Yunyan;  Yang, Dongdong;  Li, Tingting;  Li, Fudong;  Sun, Linchong;  Wei, Haoran;  He, Kun;  Yu, Fazhi;  Zhao, Debiao;  Hu, Lan;  Xing, Songge;  Liu, Zhaoji;  Li, Kui;  Guo, Jing;  Yang, Zhenye;  Pan, Xin;  Li, Ailing;  Shi, Yunyu;  Wang, Junfeng;  Gao, Ping;  Zhang, Huafeng
浏览  |  Adobe PDF(1933Kb)  |  收藏  |  浏览/下载：89/43  |  提交时间：2019/02/28
Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders 期刊论文
JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 卷号: 214, 期号: 11, 页码: 3219-3238
作者:  Jiang, Hua;  He, Hongbin;  Chen, Yun;  Huang, Wei;  Cheng, Jinbo;  Ye, Jin;  Wang, Aoli;  Tao, Jinhui;  Wang, Chao;  Liu, Qingsong;  Jin, Tengchuan;  Jiang, Wei;  Deng, Xianming;  Zhou, Rongbin
浏览  |  Adobe PDF(2740Kb)  |  收藏  |  浏览/下载：220/155  |  提交时间：2019/06/17
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10028Kb)  |  收藏  |  浏览/下载：77/31  |  提交时间：2019/06/17
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21274/11466  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
JQ1 synergizes with the Bcl-2 inhibitor ABT-263 against MYCN-amplified small cell lung cancer 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 49, 页码: 86312-86324
作者:  Wang, Huogang;  Hong, Bo;  Li, Xuemin;  Deng, Ke;  Li, Hong;  Lui, Vivian Wai Yan;  Lin, Wenchu
浏览  |  Adobe PDF(9738Kb)  |  收藏  |  浏览/下载：91/39  |  提交时间：2018/08/17
Small Cell Lung Cancer  N-myc  Bcl-2  Jq1  Abt-263  
新型不可逆BTK激酶抑制剂的发现研究 学位论文
, 北京: 中国科学院研究生院, 2017
作者:  邓远欣
Adobe PDF(2196Kb)  |  收藏  |  浏览/下载：629/1  |  提交时间：2018/01/17
Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 545-557
作者:  Wang, Beilei;  Deng, Yuanxin;  Chen, Yongfei;  Yu, Kailin;  Wang, Aoli;  Liang, Qianmao;  Wang, Wei;  Chen, Cheng;  Wu, Hong;  Hu, Chen;  Miao, Weili;  Hur, Wooyoung;  Wang, Wenchao;  Hu, Zhenquan;  Weisberg, Ellen L.;  Wang, Jinhua;  Ren, Tao;  Wang, Yinsheng;  Gray, Nathanael S.;  Liu, Qingsong;  Liu, Jing
收藏  |  浏览/下载：343/0  |  提交时间：2018/08/16
Btk  Kinase Inhibitor  Irreversible Inhibitor  Structure-activity Relationship  B-cell Lymphoma  
高尔基体蛋白STK16和G蛋白GNG7在有丝分裂和膜转运中的功能研究 学位论文
, 合肥: 中国科学技术大学, 2017
作者:  刘娟娟
Adobe PDF(6840Kb)  |  收藏  |  浏览/下载：46/3  |  提交时间：2018/01/18
油桐花发育及其性别决定机制研究 学位论文
, 合肥: 中国科学技术大学, 2017
作者:  毛颖基
Adobe PDF(7357Kb)  |  收藏  |  浏览/下载：53/0  |  提交时间：2018/01/18