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Decline in serum progastrin-releasing peptide predicts the response of patients with small cell lung cancer to chemotherapy 期刊论文
ONCOLOGY LETTERS, 2020, 卷号: 20
作者:  Li, Ming;  Han, Dandan;  Wang, Wei;  Zhang, Yang;  Li, Dan;  Dai, Chunyang;  Qian, Liting;  Lin, Wenchu
收藏  |  浏览/下载：46/0  |  提交时间：2020/12/28
progastrin-releasing peptide  therapeutic monitoring  small-cell lung cancer  neuron-specific enolase  
Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 1, 页码: 52-64
作者:  Deng, Ke;  Shen, Jiawei;  Wang, Wei;  Li, Ming;  Li, Hong;  Chen, Cheng;  Zhao, Huan;  Zhang, Mei;  Xue, Tian;  Liu, Qingsong;  Lui, Vivian Wai Yan;  Hong, Bo;  Lin, Wenchu
浏览  |  Adobe PDF(3554Kb)  |  收藏  |  浏览/下载：67/27  |  提交时间：2020/03/31
small cell lung cancer  digoxin  NaCl  cardiac glycosides  ATP1A1  
Association between Chinese Medicine Therapy and Survival Outcomes in Postoperative Patients with NSCLC: A Multicenter, Prospective, Cohort Study 期刊论文
CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 2019, 卷号: 25
作者:  Wang Xueqian;  Zhang Ying;  Hou Wei;  Wang Yingtian;  Zheng Jiabin;  Li Jie;  Lin Lizhu;  Jiang Yilan;  Wang Shenyu;  Xie Ying;  Zhang Hongliang;  Shu Qijin;  Li Ping;  Wang Wei;  You Jianliang;  Li Ge;  Liu Jie;  Fan Huiting;  Zhang Meiying;  Lin Hongsheng
收藏  |  浏览/下载：22/0  |  提交时间：2020/10/26
CELL LUNG-CANCER  ADJUVANT CHEMOTHERAPY  Chinese medicine  non-small cell lung cancer  postoperative care  cohort study  disease-free survival  
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
作者:  Wang, Beilei;  Wu, Jiaxin;  Wu, Yun;  Chen, Cheng;  Zou, Fengming;  Wang, Aoli;  Wu, Hong;  Hu, Zhenquan;  Jiang, Zongru;  Liu, Qingwang;  Wang, Wei;  Zhang, Yicong;  Liu, Feiyang;  Zhao, Ming;  Hu, Jie;  Huang, Tao;  Ge, Juan;  Wang, Li;  Ren, Tao;  Wang, Yuxin;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：25/0  |  提交时间：2019/12/25
CDK9  Kinase inhibitor  Structure-activity relationship  Leukemia  
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
作者:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.;  Wang, Beilei;  Wang, Aoli;  Wang, Wei;  Chen, Cheng;  Liu, Xiaochuan;  Jiang, Zongru;  Hu, Zhenquan;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5108Kb)  |  收藏  |  浏览/下载：589/505  |  提交时间：2019/06/10
PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL  
Discovery of N-(5-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxy-2-(4-methyl-1,4-diazepan-1-yl)phenyl)acrylamide (CHMFL-ALK/EGFR-050) as a potent ALK/EGFR dual kinase inhibitor capable of overcoming a variety of ALK/EGFR associated drug resistant mutants in NSCLC 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 期号: 无, 页码: 674-697
作者:  Chen, Yongfei;  Wu, Jiaxin;  Wang, Aoli;  Qi, Ziping;  Jiang, Taoshan;  Chen, Cheng;  Zou, Fengming;  Hu, Chen;  Wang, Wei;  Wu, Hong;  Hu, Zhenquan;  Wang, Wenchao;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(12656Kb)  |  收藏  |  浏览/下载：21275/11466  |  提交时间：2018/08/17
Egfr  Alk  Dual Kinase Inhibitor  Non-small Cell Lung Cancer  
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:  Wang, Aoli;  Li, Xixiang;  Wu, Hong;  Zou, Fengming;  Yan, Xiao-E;  Chen, Cheng;  Hu, Chen;  Yu, Kailin;  Wang, Wenchao;  Zhao, Peng;  Wu, Jiaxin;  Qi, Ziping;  Wang, Wei;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：27/0  |  提交时间：2018/07/26
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:  Wang, Aoli;  Li, Xixiang;  Wu, Hong;  Zou, Fengming;  Yan, Xiao-E;  Chen, Cheng;  Hu, Chen;  Yu, Kailin;  Wang, Wenchao;  Zhao, Peng;  Wu, Jiaxin;  Qi, Ziping;  Wang, Wei;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：48/0  |  提交时间：2018/07/26
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:  Wang, Aoli;  Li, Xixiang;  Wu, Hong;  Zou, Fengming;  Yan, Xiao-E;  Chen, Cheng;  Hu, Chen;  Yu, Kailin;  Wang, Wenchao;  Zhao, Peng;  Wu, Jiaxin;  Qi, Ziping;  Wang, Wei;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：32/0  |  提交时间：2018/07/26
Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2944-2962
作者:  Wang, Aoli;  Li, Xixiang;  Wu, Hong;  Zou, Fengming;  Yan, Xiao-E;  Chen, Cheng;  Hu, Chen;  Yu, Kailin;  Wang, Wenchao;  Zhao, Peng;  Wu, Jiaxin;  Qi, Ziping;  Wang, Wei;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：37/0  |  提交时间：2018/07/26