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HFCAS OpenIR
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Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy 期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:  Hua, Chen;  Shena, Lijuan;  Zoua, Fengming;  Wua, Yun;  Wanga, Beilei;  Wanga, Aoli;  Wud, Chao;  Wanga, Li;  Liua, Jing;  Wanga, Wenchao;  Liua, Qingsong
收藏  |  浏览/下载：34/0  |  提交时间：2023/11/10
Acquired resistance mutations  CDK9 inhibitors  Transcription  Single nucleotide polymorphisms  BAY1251152  
CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancers 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:  Cao, Jiang-yan;  Qi, Shuang;  Wu, Hong;  Wang, Ao-li;  Liu, Qing-wang;  Li, Xi-xiang;  Wang, Bei-lei;  Ge, Juan;  Zou, Feng-ming;  Chen, Cheng;  Wang, Jun-jie;  Hu, Chen;  Liu, Jing;  Wang, Wen-chao;  Liu, Qing-song
收藏  |  浏览/下载：94/0  |  提交时间：2022/03/28
HER2  breast cancers  gastric cancers  irreversible inhibitor  drug resistance  
Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2 期刊论文
LEUKEMIA, 2022
作者:  Yang, Jing;  Weisberg, Ellen L.;  Qi, Shuang;  Ni, Wei;  Mei, Husheng;  Wang, Zuowei;  Meng, Chengcheng;  Zhang, Shengzhe;  Hou, Mingqi;  Qi, Ziping;  Wang, Aoli;  Jiang, Yunyun;  Jiang, Zongru;  Huang, Tao;  Liu, Qingwang;  Magin, Robert S.;  Doherty, Laura;  Wang, Wenchao;  Liu, Jing;  Buhrlage, Sara J.;  Liu, Qingsong;  Griffin, James D.
收藏  |  浏览/下载：76/0  |  提交时间：2022/02/14
An overview of kinase downregulators and recent advances in discovery approaches 期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6
作者:  Wang, Beilei;  Wu, Hong;  Hu, Chen;  Wang, Haizhen;  Liu, Jing;  Wang, Wenchao;  Liu, Qingsong
收藏  |  浏览/下载：72/0  |  提交时间：2022/01/25
Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020
作者:  Wang, Wen-liang;  Jiang, Zong-ru;  Hu, Chen;  Chen, Cheng;  Hu, Zhen-quan;  Wang, Ao-li;  Wang, Li;  Liu, Jing;  Wang, Wen-chao;  Liu, Qing-song
收藏  |  浏览/下载：57/0  |  提交时间：2020/11/26
PGK1  NG52  kinase inhibitor  Warburg effect  glioma  
Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020
作者:  Chen, Cheng;  Cheng, Chuan-dong;  Wu, Hong;  Wang, Zuo-wei;  Wang, Li;  Jiang, Zong-ru;  Wang, Ao-li;  Hu, Chen;  Dong, Yong-fei;  Niu, Wan-xiang;  Qi, Shuang;  Qi, Zi-ping;  Liu, Jing;  Wang, Wen-chao;  Niu, Chao-shi;  Liu, Qing-song
浏览  |  Adobe PDF(3476Kb)  |  收藏  |  浏览/下载：95/35  |  提交时间：2020/11/26
glioblastoma  osimertinib  temozolamide  MAPK-signaling pathway  MNK  eukaryotic translation initiation factor 4E  
Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent 期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10
作者:  Jiang, Zongru;  Wang, Li;  Liu, Xuesong;  Chen, Cheng;  Wang, Beilei;  Wang, Wenliang;  Hu, Chen;  Yu, Kailin;  Qi, Ziping;  Liu, Qingwang;  Wang, Aoli;  Liu, Jing;  Hong, Guangchen;  Wang, Wenchao;  Liu, Qingsong
收藏  |  浏览/下载：51/0  |  提交时间：2020/11/26
Cancer  VEGFR2 kinase  Kinase inhibitor  Angiogenesis  Inhibitor selectivity  
Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
作者:  Wu, Jiaxin;  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Qi, Ziping;  Hu, Chen;  Wang, Wenliang;  Wu, Hong;  Huang, Tao;  Zhao, Ming;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Li, Lili;  Ge, Jian;  Ren, Tao;  Xia, Ruixiang;  Liu, Jing
收藏  |  浏览/下载：52/0  |  提交时间：2019/11/27
BCR-ABL  PDGFR  chronic myeloid leukemia  kinase inhibitor  
Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019
作者:  Yun Wu;  Beilei Wang;  Junjie Wang;  Qi S(亓爽);  Fengming Zou;  Ziping Qi;  Feiyang Liu;  Wenchao Wang;  Qingsong Liu;  Jing Liu
浏览  |  Adobe PDF(5207Kb)  |  收藏  |  浏览/下载：124/63  |  提交时间：2020/10/20
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892
作者:  Liang, Xiaofei;  Wang, Beilei;  Chen, Cheng;  Wang, Aoli;  Hu, Chen;  Zou, Fengming;  Yu, Kailin;  Liu, Qingwang;  Li, Feng;  Hu, Zhenquan;  Lu, Tingting;  Wang, Junjie;  Wang, Li;  Weisberg, Ellen L.;  Li, Lili;  Xia, Ruixiang;  Wang, Wenchao;  Ren, Tao;  Ge, Jian;  Liu, Jing;  Liu, Qinsong
浏览  |  Adobe PDF(13868Kb)  |  收藏  |  浏览/下载：369/319  |  提交时间：2020/05/21