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Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10028Kb)  |  收藏  |  浏览/下载：91/31  |  提交时间：2019/06/17
c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice 期刊论文
DIABETOLOGIA, 2017, 卷号: 60, 期号: 5, 页码: 900-910
作者:  Wu, Rong;  Sun, Jian-guang;  Wang, Ji-qiu;  Li, Binhua;  Liu, Qingsong;  Ning, Guang;  Jin, Wanzhu;  Yuan, Zengqiang
收藏  |  浏览/下载：47/0  |  提交时间：2018/07/26
针对FLT3-ITD阳性急性髓细胞白血病的激酶抑制剂药物学研究 学位论文
, 合肥: 中国科学技术大学, 2017
作者:  王傲莉
Adobe PDF(7111Kb)  |  收藏  |  浏览/下载：143/0  |  提交时间：2018/01/18
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxybenzamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 1793-1816
作者:  Liang, Xiaofei;  Lv, Fengchao;  Wang, Beilei;  Yu, Kailin;  Wu, Hong;  Qi, Ziping;  Jiang, Zongru;  Chen, Cheng;  Wang, Aoli;  Miao, Weili;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Liu, Xiaochuan;  Zhao, Zheng;  Wang, Li;  Zhang, Shanchuan;  Ye, Zi;  Wang, Chu;  Ren, Tao;  Wang, Yinsheng;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5919Kb)  |  收藏  |  浏览/下载：17309/7526  |  提交时间：2018/07/04
EpCAM Inhibition Sensitizes Chemoresistant Leukemia to Immune Surveillance 期刊论文
CANCER RESEARCH, 2017, 卷号: 77, 期号: 2, 页码: 482-493
作者:  Zheng, Xiaohu;  Fan, Xiaolei;  Fu, Binqing;  Zheng, Meijuan;  Zhang, Aimei;  Zhong, Kai;  Yan, Jialai;  Sun, Rui;  Tian, Zhigang;  Wei, Haiming
浏览  |  Adobe PDF(2088Kb)  |  收藏  |  浏览/下载：193/150  |  提交时间：2018/07/04
Discovery of 4-Methyl-N-(44(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-y1)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge Binding 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 1, 页码: 273-289
作者:  Wang, Qiang;  Liu, Feiyang;  Wang, Beilei;  Zou, Fengming;  Qi, Ziping;  Chen, Cheng;  Yu, Kailin;  Hu, Chen;  Qi, Shuang;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Wang, Wei;  Wang, Li;  Liang, Qianmao;  Zhang, Shanchun;  Ren, Tao;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(3516Kb)  |  收藏  |  浏览/下载：110/60  |  提交时间：2018/07/04
一种高活性高选择性Type Ⅱ不可逆 BMX 激酶抑制剂的开发 学位论文
, 合肥: 中国科学技术大学, 2017
作者:  吕凤超
Adobe PDF(2693Kb)  |  收藏  |  浏览/下载：50/0  |  提交时间：2018/01/18