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Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
作者:  Wu, Jiaxin;  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Qi, Ziping;  Hu, Chen;  Wang, Wenliang;  Wu, Hong;  Huang, Tao;  Zhao, Ming;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Li, Lili;  Ge, Jian;  Ren, Tao;  Xia, Ruixiang;  Liu, Jing
收藏  |  浏览/下载：52/0  |  提交时间：2019/11/27
BCR-ABL  PDGFR  chronic myeloid leukemia  kinase inhibitor  
Pulsed laser assisted synthesis of gadolinium carbide/carbon shell dots with enhanced magnetic resonance properties 期刊论文
NANOTECHNOLOGY, 2019, 卷号: 30, 期号: 10, 页码: 11
作者:  Zhu, Zhifeng;  Sun, Hongbin;  Jin, Juan;  Wang, Menglin;  Zhang, Yan;  Yu, Dabin;  Jiang, Yang
浏览  |  Adobe PDF(1883Kb)  |  收藏  |  浏览/下载：70/25  |  提交时间：2020/03/31
pulsed laser irradiation  gadolinium carbide/carbon shell dots  magnetic resonance  relaxivity  
Nitrogen and boron dual-doped graphene quantum dots for near-infrared second window imaging and photothermal therapy 期刊论文
APPLIED MATERIALS TODAY, 2019, 卷号: 14, 期号: 无, 页码: 108-117
作者:  Wang, Hui;  Mu, Qingxin;  Wang, Kui;  Revia, Richard A.;  Yen, Charles;  Gu, Xinyu;  Tian, Bowei;  Liu, Jun;  Zhang, Miqin
浏览  |  Adobe PDF(3141Kb)  |  收藏  |  浏览/下载：1671/137  |  提交时间：2020/05/21
Theranostic nanoparticle  NIR II fluorescence imaging  Graphene quantum dot  Photothermal effect  Cancer therapy  
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892
作者:  Liang, Xiaofei;  Wang, Beilei;  Chen, Cheng;  Wang, Aoli;  Hu, Chen;  Zou, Fengming;  Yu, Kailin;  Liu, Qingwang;  Li, Feng;  Hu, Zhenquan;  Lu, Tingting;  Wang, Junjie;  Wang, Li;  Weisberg, Ellen L.;  Li, Lili;  Xia, Ruixiang;  Wang, Wenchao;  Ren, Tao;  Ge, Jian;  Liu, Jing;  Liu, Qinsong
浏览  |  Adobe PDF(13868Kb)  |  收藏  |  浏览/下载：369/319  |  提交时间：2020/05/21
Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 1, 页码: 52-64
作者:  Deng, Ke;  Shen, Jiawei;  Wang, Wei;  Li, Ming;  Li, Hong;  Chen, Cheng;  Zhao, Huan;  Zhang, Mei;  Xue, Tian;  Liu, Qingsong;  Lui, Vivian Wai Yan;  Hong, Bo;  Lin, Wenchu
浏览  |  Adobe PDF(3554Kb)  |  收藏  |  浏览/下载：67/27  |  提交时间：2020/03/31
small cell lung cancer  digoxin  NaCl  cardiac glycosides  ATP1A1  
The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China 期刊论文
CANCER MANAGEMENT AND RESEARCH, 2019, 卷号: 11, 期号: 无, 页码: 1473-1492
作者:  Wu, Haibo;  Wang, Wei;  Du, Jun;  Li, Hong;  Wang, Huogang;  Huang, Liangliang;  Xiang, Hang;  Xie, Jing;  Liu, Xiaoli;  Li, Heng;  Lin, Wenchu
浏览  |  Adobe PDF(1845Kb)  |  收藏  |  浏览/下载：192/159  |  提交时间：2020/05/21
breast cancer  PIK3CA  clinicopathological characteristics  prognosis  
Is level of acetylation directly correlated to radiation sensitivity of cancer cell? 期刊论文
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2019, 卷号: 813, 期号: 无, 页码: 13-19
作者:  Zhang, Fengqiu;  Chen, Zhu;  Shao, Changsheng;  Huang, Qing
浏览  |  Adobe PDF(3552Kb)  |  收藏  |  浏览/下载：57/20  |  提交时间：2020/03/31
Acetylation  Radiosensitivity  HeLa cells  Histone deacetylase inhibitors (HDACis)  Trichostatin A (TSA)  
The ratio of Bcl-2/Bim as a predictor of cisplatin response provides a rational combination of ABT-263 with cisplatin or radiation in small cell lung cancer 期刊论文
CANCER BIOMARKERS, 2019, 卷号: 24, 期号: 1, 页码: 51-59
作者:  Li, Hong;  Wang, Huogang;  Deng, Ke;  Han, Wei;  Hong, Bo;  Lin, Wenchu
浏览  |  Adobe PDF(5535Kb)  |  收藏  |  浏览/下载：80/34  |  提交时间：2020/05/21
Small cell lung cancer  Bcl-2  Bim  ABT-263  cisplatin  radiation  
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  收藏  |  浏览/下载：190/104  |  提交时间：2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Effects of 3.7 T-24.5 T high magnetic fields on tumor-bearing mice 期刊论文
CHINESE PHYSICS B, 2018, 卷号: 27, 期号: 11, 页码: 10
作者:  Tian, Xiaofei;  Wang, Ze;  Zhang, Lei;  Xi, Chuanying;  Pi, Li;  Qi, Ziping;  Lu, Qingyou;  Zhang, Xin
收藏  |  浏览/下载：38/0  |  提交时间：2019/12/25
static magnetic field (SMF)  high magnetic field (MF)  tumor  magnetic field gradient