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HFCAS OpenIR

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Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
作者:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  收藏  |  浏览/下载：190/104  |  提交时间：2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Strategy Design and Transient Analysis of ITER PPEN Transformer On-Load Tap Changer During Converter Operation 期刊论文
JOURNAL OF FUSION ENERGY, 2018, 卷号: 37, 期号: 6, 页码: 346-353
作者:  Fan, Renjing;  Fu, Peng;  Tao, Jun;  Gao, Ge;  Song, Zhiquan;  Huang, Liansheng;  Chen, Xiaojiao;  Li, Jinchao
收藏  |  浏览/下载：32/0  |  提交时间：2019/12/25
ITER  Coil power supply  OLTC control  Hysteresis band  Converter operation robustness  
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
作者:  Wang, Beilei;  Wu, Jiaxin;  Wu, Yun;  Chen, Cheng;  Zou, Fengming;  Wang, Aoli;  Wu, Hong;  Hu, Zhenquan;  Jiang, Zongru;  Liu, Qingwang;  Wang, Wei;  Zhang, Yicong;  Liu, Feiyang;  Zhao, Ming;  Hu, Jie;  Huang, Tao;  Ge, Juan;  Wang, Li;  Ren, Tao;  Wang, Yuxin;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：25/0  |  提交时间：2019/12/25
CDK9  Kinase inhibitor  Structure-activity relationship  Leukemia  
Observation of toroidal Alfven eigenmode excited by energetic electrons induced by static magnetic perturbations in the EAST tokamak 期刊论文
NUCLEAR FUSION, 2018, 卷号: 58, 期号: 10, 页码: 5
作者:  Chu, N.;  Sun, Y.;  Gu, S.;  Wang, H. H.;  Hu, Y. J.;  Shi, T. H.;  Chen, D. L.;  Gu, X.;  He, K. Y.;  Jia, M.;  Lin, S. Y.;  Liu, H. Q.;  Qian, J. P.;  Ren, J.;  Shen, B.;  Ti, A.;  Wang, S. X.;  Xie, J. L.;  Xu, M.;  Xue, M. M.;  Yan, N.;  Zang, Q.;  Zeng, L.;  Zhang, J. Z.;  Zhang, T.;  Zhang, Y.;  Zhong, G. Q.;  Zhou, C.;  Zhou, R. J.
收藏  |  浏览/下载：48/0  |  提交时间：2019/11/11
magnetic perturbation  toroidal Alfven eignenmode  reconnection  magnetic island  energetic electron  
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384
作者:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E.;  Wang, Beilei;  Wang, Aoli;  Wang, Wei;  Chen, Cheng;  Liu, Xiaochuan;  Jiang, Zongru;  Hu, Zhenquan;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5108Kb)  |  收藏  |  浏览/下载：589/505  |  提交时间：2019/06/10
PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL