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HFCAS OpenIR

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Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
作者:  Wang, Beilei;  Wu, Jiaxin;  Wu, Yun;  Chen, Cheng;  Zou, Fengming;  Wang, Aoli;  Wu, Hong;  Hu, Zhenquan;  Jiang, Zongru;  Liu, Qingwang;  Wang, Wei;  Zhang, Yicong;  Liu, Feiyang;  Zhao, Ming;  Hu, Jie;  Huang, Tao;  Ge, Juan;  Wang, Li;  Ren, Tao;  Wang, Yuxin;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：25/0  |  提交时间：2019/12/25
CDK9  Kinase inhibitor  Structure-activity relationship  Leukemia  
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3K delta) inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 156, 页码: 831-846
作者:  Liang, Xiaofei;  Li, Feng;  Chen, Cheng;  Jiang, Zongru;  Wang, Aoli;  Liu, Xiaochuan;  Ge, Juan;  Hu, Zhenquan;  Yu, Kailin;  Wang, Wenliang;  Zou, Fengming;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Zhang, Shanchun;  Wang, Yuxin;  Liu, Qingsong;  Liu, Jing
收藏  |  浏览/下载：51/0  |  提交时间：2019/12/10
PI3K delta  Kinase inhibitor  Acute myeloid leukemia  Structure-activity relationship  
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
作者:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(10028Kb)  |  收藏  |  浏览/下载：78/31  |  提交时间：2019/06/17
Highly Sensitive Detection of Ionizing Radiations by a Photoluminescent Uranyl Organic Framework 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 卷号: 56, 期号: 26, 页码: 7500-7504
作者:  Xie, Jian;  Wang, Yaxing;  Liu, Wei;  Yin, Xuemiao;  Chen, Lanhua;  Zou, Youming;  Diwu, Juan;  Chai, Zhifang;  Albrecht-Schmitt, Thomas E.;  Liu, Guokui;  Wang, Shuao
浏览  |  Adobe PDF(2289Kb)  |  收藏  |  浏览/下载：149/90  |  提交时间：2018/05/25
Ionizing Radiation  Photoluminescence  Radicals  Uranium  Uranyl-organic Frameworks  
Carrier balance and linear magnetoresistance in type- II Weyl semimetal WTe2 期刊论文
FRONTIERS OF PHYSICS, 2017, 卷号: 12, 期号: 3, 页码: 1-8
作者:  Pan, Xing-Chen;  Pan, Yiming;  Jiang, Juan;  Zuo, Huakun;  Liu, Huimei;  Chen, Xuliang;  Wei, Zhongxia;  Zhang, Shuai;  Wang, Zhihe;  Wan, Xiangang;  Yang, Zhaorong;  Feng, Donglai;  Xia, Zhengcai;  Li, Liang;  Song, Fengqi;  Wang, Baigeng;  Zhang, Yuheng;  Wang, Guanghou
浏览  |  Adobe PDF(1760Kb)  |  收藏  |  浏览/下载：110/53  |  提交时间：2018/07/04
Wte2  Type-ii Weyl Semimetal  Carrier Balance  Linear Magnetoresistance  
Carrier balance and linear magnetoresistance in type- II Weyl semimetal WTe2 期刊论文
FRONTIERS OF PHYSICS, 2017, 卷号: 12, 期号: 3, 页码: 1-8
作者:  Pan, Xing-Chen;  Pan, Yiming;  Jiang, Juan;  Zuo, Huakun;  Liu, Huimei;  Chen, Xuliang;  Wei, Zhongxia;  Zhang, Shuai;  Wang, Zhihe;  Wan, Xiangang;  Yang, Zhaorong;  Feng, Donglai;  Xia, Zhengcai;  Li, Liang;  Song, Fengqi;  Wang, Baigeng;  Zhang, Yuheng;  Wang, Guanghou
浏览  |  Adobe PDF(1760Kb)  |  收藏  |  浏览/下载：192/136  |  提交时间：2018/07/04
Wte2  Type-ii Weyl Semimetal  Carrier Balance  Linear Magnetoresistance  
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxybenzamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 1793-1816
作者:  Liang, Xiaofei;  Lv, Fengchao;  Wang, Beilei;  Yu, Kailin;  Wu, Hong;  Qi, Ziping;  Jiang, Zongru;  Chen, Cheng;  Wang, Aoli;  Miao, Weili;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Liu, Xiaochuan;  Zhao, Zheng;  Wang, Li;  Zhang, Shanchuan;  Ye, Zi;  Wang, Chu;  Ren, Tao;  Wang, Yinsheng;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5919Kb)  |  收藏  |  浏览/下载：17293/7523  |  提交时间：2018/07/04
Discovery of 4-Methyl-N-(44(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-y1)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge Binding 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 1, 页码: 273-289
作者:  Wang, Qiang;  Liu, Feiyang;  Wang, Beilei;  Zou, Fengming;  Qi, Ziping;  Chen, Cheng;  Yu, Kailin;  Hu, Chen;  Qi, Shuang;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Wang, Wei;  Wang, Li;  Liang, Qianmao;  Zhang, Shanchun;  Ren, Tao;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(3516Kb)  |  收藏  |  浏览/下载：99/57  |  提交时间：2018/07/04
Amplification of arsenic genotoxicity by TiO2 nanoparticles in mammalian cells: new insights from physicochemical interactions and mitochondria 期刊论文
NANOTOXICOLOGY, 2017, 卷号: 11, 期号: 8, 页码: 978-995
作者:  Wang, Xinan;  Liu, Yun;  Wang, Juan;  Nie, Yaguang;  Chen, Shaopeng;  Hei, Tom K.;  Deng, Zhaoxiang;  Wu, Lijun;  Zhao, Guoping;  Xu, An
浏览  |  Adobe PDF(2539Kb)  |  收藏  |  浏览/下载：128/35  |  提交时间：2019/02/28
TiO2 nanoparticles (TiO2 NPs)  arsenic [As(III)]  human-hamster hybrid (A(L)) cells  synergistic genotoxicity  physicochemical interactions  mitochondria  
Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 11, 页码: 18359-18372
作者:  Hu, Chen;  Wang, Aoli;  Wu, Hong;  Qi, Ziping;  Li, Xixiang;  Yan, Xiao-E;  Chen, Cheng;  Yu, Kailin;  Zou, Fengming;  Wang, Wenchao;  Wang, Wei;  Wu, Jiaxin;  Liu, Juan;  Wang, Beilei;  Wang, Li;  Ren, Tao;  Zhang, Shanchun;  Yun, Cai-Hong;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(6153Kb)  |  收藏  |  浏览/下载：178/46  |  提交时间：2018/07/04
Egfr  Egfrt790m  Nsclc  Kinase Inhibitors  Drug Resistance