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Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243
作者:  Liang, Xiaofei;  Wang, Chun;  Wang, Beilei;  Liu, Juan;  Qi, Shuang;  Wang, Aoli;  Liu, Qingwang;  Deng, Maoqing;  Wang, Li;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：37/0  |  提交时间：2022/12/23
CSF1R inhibitor  Kinase inhibitor  Macrophage polarization  
PEG-Bottlebrush Stabilizer-Based Worm-like Nanocrystal Micelles with Long-Circulating and Controlled Release for Delivery of a BCR-ABL Inhibitor against Chronic Myeloid Leukemia (CML) 期刊论文
PHARMACEUTICS, 2022, 卷号: 14
作者:  Liang, Huamin;  Zou, Fengming;  Fu, Liyi;  Liu, Qingwang;  Wang, Beilei;  Liang, Xiaofei;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：43/0  |  提交时间：2022/12/23
drug nanocrystal  stabilizer  micelle  BCR-ABL  chronic myeloid leukemia (CML)  
Nanocrystal-loaded liposome for targeted delivery of poorly water-soluble antitumor drugs with high drug loading and stability towards efficient cancer therapy 期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 卷号: 599
作者:  Liang, Huamin;  Zou, Fengming;  Liu, Qingwang;  Wang, Beilei;  Fu, Liyi;  Liang, Xiaofei;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：46/0  |  提交时间：2021/05/17
Liposome  Drug nanocrystal  Core-shell  Drug delivery  Tumor therapy  BCR-ABL  
Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia 期刊论文
HAEMATOLOGICA, 2021, 卷号: 106
作者:  Wang, Aoli;  Hu, Chen;  Chen, Cheng;  Liang, Xiaofei;  Wang, Beilei;  Zou, Fengming;  Yu, Kailin;  Li, Feng;  Liu, Qingwang;  Qi, Ziping;  Wang, Junjie;  Wang, Wenliang;  Wang, Li;  Weisberg, Ellen L.;  Wang, Wenchao;  Li, Lili;  Ge, Jian;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
收藏  |  浏览/下载：47/0  |  提交时间：2021/04/26
An ultra-long circulating nanoparticle for reviving a highly selective BCR-ABL inhibitor in long-term effective and safe treatment of chronic myeloid leukemia 期刊论文
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2020, 卷号: 29
作者:  Fu, Liyi;  Zou, Fengming;  Liu, Qingwang;  Wang, Beilei;  Wang, Junqing;  Liang, Huamin;  Liang, Xiaofei;  Liu, Jing;  Shi, Jinjun;  Liu, Qingsong
收藏  |  浏览/下载：37/0  |  提交时间：2020/11/30
Chronic myeloid leukemia  BCR-ABL  Long-circulating nanoparticle  Drug delivery  
Discovery of 6 '-chloro-N-methyl-5 '-(phenylsulfonamido)-[3,3 '-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188
作者:  Liang, Xiaofei;  Jiang, Zongru;  Huang, Zhenghui;  Li, Feng;  Chen, Cheng;  Hu, Chen;  Wang, Wenliang;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Qi, Ziping;  Liu, Jing;  Jiang, Lubin;  Liu, Qingsong
收藏  |  浏览/下载：52/0  |  提交时间：2020/11/26
PI4K kinase  Kinase inhibitor  Malaria  Blood stage  Liver stage  
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892
作者:  Liang, Xiaofei;  Wang, Beilei;  Chen, Cheng;  Wang, Aoli;  Hu, Chen;  Zou, Fengming;  Yu, Kailin;  Liu, Qingwang;  Li, Feng;  Hu, Zhenquan;  Lu, Tingting;  Wang, Junjie;  Wang, Li;  Weisberg, Ellen L.;  Li, Lili;  Xia, Ruixiang;  Wang, Wenchao;  Ren, Tao;  Ge, Jian;  Liu, Jing;  Liu, Qinsong
浏览  |  Adobe PDF(13868Kb)  |  收藏  |  浏览/下载：362/319  |  提交时间：2020/05/21
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3K delta) inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 156, 页码: 831-846
作者:  Liang, Xiaofei;  Li, Feng;  Chen, Cheng;  Jiang, Zongru;  Wang, Aoli;  Liu, Xiaochuan;  Ge, Juan;  Hu, Zhenquan;  Yu, Kailin;  Wang, Wenliang;  Zou, Fengming;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Zhang, Shanchun;  Wang, Yuxin;  Liu, Qingsong;  Liu, Jing
收藏  |  浏览/下载：45/0  |  提交时间：2019/12/10
PI3K delta  Kinase inhibitor  Acute myeloid leukemia  Structure-activity relationship  
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxybenzamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 1793-1816
作者:  Liang, Xiaofei;  Lv, Fengchao;  Wang, Beilei;  Yu, Kailin;  Wu, Hong;  Qi, Ziping;  Jiang, Zongru;  Chen, Cheng;  Wang, Aoli;  Miao, Weili;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Liu, Xiaochuan;  Zhao, Zheng;  Wang, Li;  Zhang, Shanchuan;  Ye, Zi;  Wang, Chu;  Ren, Tao;  Wang, Yinsheng;  Liu, Qingsong;  Liu, Jing
浏览  |  Adobe PDF(5919Kb)  |  收藏  |  浏览/下载：17292/7523  |  提交时间：2018/07/04
Simultaneous inhibition of Vps34 kinase would enhance PI3K delta inhibitor cytotoxicity in the B-cell malignancies 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 33, 页码: 53515-53525
作者:  Liu, Xiaochuan;  Wang, Aoli;  Liang, Xiaofei;  Liu, Juanjuan;  Zou, Fengming;  Chen, Cheng;  Zhao, Zheng;  Deng, Yuanxin;  Wu, Hong;  Qi, Ziping;  Wang, Beilei;  Wang, Li;  Liu, Feiyang;  Xu, Yunhe;  Wang, Wenchao;  Fernandes, Stacey M.;  Stone, Richard M.;  Galinsky, Ilene A.;  Brown, Jennifer R.;  Loh, Teckpeng;  Griffin, James. D.;  Zhang, Shanchun;  Weisberg, Ellen L.;  Zhang, Xin;  Liu, Jing;  Liu, Qingsong
浏览  |  Adobe PDF(7625Kb)  |  收藏  |  浏览/下载：88/37  |  提交时间：2017/11/21
Pi3k Delta  Vps34  Combination  Chronic Lymphatic Leukemia  Acute Myeloid Leukemia