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Seismic Analysis Under SL-1 of New Structure Support Frame for ITER PF Converter System 期刊论文
IEEE TRANSACTIONS ON PLASMA SCIENCE, 2022
Authors:  Zhang, Jie;  Jiang, Li;  Huang, Zhengyi;  Xu, Xuesong;  Wu, Peng;  Lei, Hong
Favorite  |  View/Download：53/0  |  Submit date：2022/12/23
International Thermonuclear Experimental Reactor (ITER)  poloidal field (PF) converter  seismic analysis  support frame  
Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2 期刊论文
LEUKEMIA, 2022
Authors:  Yang, Jing;  Weisberg, Ellen L.;  Qi, Shuang;  Ni, Wei;  Mei, Husheng;  Wang, Zuowei;  Meng, Chengcheng;  Zhang, Shengzhe;  Hou, Mingqi;  Qi, Ziping;  Wang, Aoli;  Jiang, Yunyun;  Jiang, Zongru;  Huang, Tao;  Liu, Qingwang;  Magin, Robert S.;  Doherty, Laura;  Wang, Wenchao;  Liu, Jing;  Buhrlage, Sara J.;  Liu, Qingsong;  Griffin, James D.
Favorite  |  View/Download：91/0  |  Submit date：2022/02/14
Microstructure evolution of pure tungsten after low-energy and high-fluence He+ implantation assessed by synchrotron grazing incidence X-ray diffraction 期刊论文
JOURNAL OF NUCLEAR MATERIALS, 2021, 卷号: 544
Authors:  Huang, W. J.;  Sun, M.;  Yang, J. F.;  Wen, W.;  Xie, Z. M.;  Zhang, L. C.;  Liu, R.;  Chen, C. A.;  Jiang, Y.;  Wang, X. P.;  Wu, X. B.;  Fang, Q. F.
Favorite  |  View/Download：73/0  |  Submit date：2021/03/15
Helium ion implantation  Tungsten  Synchrotron X-Ray diffraction  Nanoindentation  
Uniform manganese-loaded titanium dioxide nanotube arrays for accurate detection of trace Cd2+ in water, soil and tea: Enhanced stability and sensitivity 期刊论文
CHEMICAL ENGINEERING JOURNAL, 2020, 卷号: 400
Authors:  Jiang, Min;  Ma, Ming-Jun;  Lin, Chu-Hong;  Yang, Meng;  Fang, Li;  Liu, Jin-Huai;  Zhao, Nan-Jing;  Huang, Xing-Jiu
Favorite  |  View/Download：125/0  |  Submit date：2020/11/30
Self-organizing and ordered Mn-TiO2 NTAs  ECP-LIBS  MATLAB  Simulation  High stability and sensitivity  
Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020
Authors:  Wang, Wen-liang;  Jiang, Zong-ru;  Hu, Chen;  Chen, Cheng;  Hu, Zhen-quan;  Wang, Ao-li;  Wang, Li;  Liu, Jing;  Wang, Wen-chao;  Liu, Qing-song
Favorite  |  View/Download：70/0  |  Submit date：2020/11/26
PGK1  NG52  kinase inhibitor  Warburg effect  glioma  
Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020
Authors:  Chen, Cheng;  Cheng, Chuan-dong;  Wu, Hong;  Wang, Zuo-wei;  Wang, Li;  Jiang, Zong-ru;  Wang, Ao-li;  Hu, Chen;  Dong, Yong-fei;  Niu, Wan-xiang;  Qi, Shuang;  Qi, Zi-ping;  Liu, Jing;  Wang, Wen-chao;  Niu, Chao-shi;  Liu, Qing-song
View  |  Adobe PDF(3476Kb)  |  Favorite  |  View/Download：113/39  |  Submit date：2020/11/26
glioblastoma  osimertinib  temozolamide  MAPK-signaling pathway  MNK  eukaryotic translation initiation factor 4E  
Discovery of 6 '-chloro-N-methyl-5 '-(phenylsulfonamido)-[3,3 '-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188
Authors:  Liang, Xiaofei;  Jiang, Zongru;  Huang, Zhenghui;  Li, Feng;  Chen, Cheng;  Hu, Chen;  Wang, Wenliang;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Qi, Ziping;  Liu, Jing;  Jiang, Lubin;  Liu, Qingsong
Favorite  |  View/Download：69/0  |  Submit date：2020/11/26
PI4K kinase  Kinase inhibitor  Malaria  Blood stage  Liver stage  
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models 期刊论文
CANCER LETTERS, 2019, 页码: 105-114
Authors:  Lu, Tingting;  Chen, Cheng;  Wang, Aoli;  Jiang, Zongru;  Qi, Ziping;  Hu, Zhenquan;  Hu, Chen;  Liu, Feiyang;  Wang, Wenliang;  Wu, Hong;  Wang, Beilei;  Wang, Li;  Qi, Shuang;  Wu, Jiaxin;  Wang, Wenchao;  Tang, Jun;  Yan, Hezhong;  Bai, Mingfeng;  Liu, Qingsong;  Liu, Jing
Favorite  |  View/Download：32/0  |  Submit date：2020/07/14
cKIT T670I mutant  Activation loop mutants  Drug resistance  
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
Authors:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  Favorite  |  View/Download：212/104  |  Submit date：2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
Authors:  Wang, Beilei;  Wu, Jiaxin;  Wu, Yun;  Chen, Cheng;  Zou, Fengming;  Wang, Aoli;  Wu, Hong;  Hu, Zhenquan;  Jiang, Zongru;  Liu, Qingwang;  Wang, Wei;  Zhang, Yicong;  Liu, Feiyang;  Zhao, Ming;  Hu, Jie;  Huang, Tao;  Ge, Juan;  Wang, Li;  Ren, Tao;  Wang, Yuxin;  Liu, Jing;  Liu, Qingsong
Favorite  |  View/Download：33/0  |  Submit date：2019/12/25
CDK9  Kinase inhibitor  Structure-activity relationship  Leukemia