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Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
Authors:  Wu, Jiaxin;  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Qi, Ziping;  Hu, Chen;  Wang, Wenliang;  Wu, Hong;  Huang, Tao;  Zhao, Ming;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Li, Lili;  Ge, Jian;  Ren, Tao;  Xia, Ruixiang;  Liu, Jing
Favorite  |  View/Download:3/0  |  Submit date:2019/11/27
BCR-ABL  PDGFR  chronic myeloid leukemia  kinase inhibitor  
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
Authors:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  Favorite  |  View/Download:55/20  |  Submit date:2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Non-Stoichiometry Effects on the Extreme Magnetoresistance in Weyl Semimetal WTe2 期刊论文
CHINESE PHYSICS LETTERS, 2018, 卷号: 35, 期号: 9, 页码: 5
Authors:  Gong, Ji-Xiang;  Yang, Jun;  Ge, Min;  Wang, Yong-Jian;  Liang, Dan-Dan;  Luo, Lei;  Yan, Xiu;  Zhen, Wei-Li;  Weng, Shi-Rui;  Pi, Li;  Zhang, Chang-Jin;  Zhu, Wen-Ka
Favorite  |  View/Download:1/0  |  Submit date:2019/12/25
Application of an empirical saturation rule to TGLF to unify low-k and high-k turbulence dominated regimes 期刊论文
NUCLEAR FUSION, 2018, 卷号: 58, 期号: 1, 页码: 1-14
Authors:  Jian, Xiang;  Chan, Vincent S.;  Chen, Jiale;  Li, Zeyu;  Garofalo, Andrea M.;  Zhuang, Ge;  CFETR Phys Team
View  |  Adobe PDF(3517Kb)  |  Favorite  |  View/Download:31/8  |  Submit date:2018/08/17
Plasma Turbulence  Tglf Model  Multi-scale Simulation  Experimental Validation  
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
Authors:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
View  |  Adobe PDF(10028Kb)  |  Favorite  |  View/Download:12/5  |  Submit date:2019/06/17
Optimization of CFETR baseline performance by controlling rotation shear and pedestal collisionality through integrated modeling 期刊论文
NUCLEAR FUSION, 2017, 卷号: 57, 期号: 4, 页码: 1-12
Authors:  Jian, Xiang;  Chen, Jiale;  Chan, Vincent S.;  Zhuang, Ge;  Li, Guoqiang;  Deng, Zhao;  Shi, Nan;  Xu, Guoliang;  Staebler, Gary M.;  Guo, Wenfeng
View  |  Adobe PDF(3708Kb)  |  Favorite  |  View/Download:14/6  |  Submit date:2018/05/17
Cfetr  Fuison Plasma  Scenario Optimization  Plasma Confinement  Density Peaking  Tglf  Intergrated Modeling  
Anomalous low-temperature heat capacity in antiperovskite compounds 期刊论文
CHINESE PHYSICS B, 2017, 卷号: 26, 期号: 2, 页码: 1-5
Authors:  Guo, Xin-Ge;  Lin, Jian-Chao;  Tong, Peng;  Lin, Shuai;  Yang, Cheng;  Lu, Wen-Jian;  Song, Wen-Hai;  Sun, Yu-Ping
View  |  Adobe PDF(539Kb)  |  Favorite  |  View/Download:18/10  |  Submit date:2018/05/25
Low-temperature Heat Capacity  Low-energy Phonon Modes  Antiperovskite Compound  Negative Thermal Expansion  
Characteristics of aerosol size distribution and vertical backscattering coefficient profile during 2014 APEC in Beijing 期刊论文
ATMOSPHERIC ENVIRONMENT, 2017, 卷号: 148, 期号: 无, 页码: 30-41
Authors:  Zhang, Jiaoshi;  Chen, Zhenyi;  Lu, Yihuai;  Gui, Huaqiao;  Liu, Jianguo;  Liu, Wenqing;  Wang, Jie;  Yu, Tongzhu;  Cheng, Yin;  Chen, Yong;  Ge, Baozhu;  Fan, Yu;  Luo, Xisheng
View  |  Adobe PDF(3174Kb)  |  Favorite  |  View/Download:36/8  |  Submit date:2018/05/04
Haze  Apec  Regional Transport  Southwest Pathway  Beijing  
Modular design and development methodology for robotic multi-axis F/M sensors 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6, 期号: 无, 页码: 1-8
Authors:  Liang, Qiao-Kang;  Zhang, Dan;  Coppola, Gianmarc;  Wu, Wan-Neng;  Zou, Kun-Lin;  Wang, Yao-Nan;  Sun, Wei;  Ge, Yun-Jian;  Ge, Yu
View  |  Adobe PDF(1393Kb)  |  Favorite  |  View/Download:15/3  |  Submit date:2017/12/18
自准直法测GdTaO4晶体折射率 期刊论文
物理学报, 2016, 卷号: 65, 期号: 8, 页码: 087801
Authors:  王小飞;  杨华军;  张戈;  张庆礼;  窦仁勤;  丁守军;  罗建乔;  刘文鹏;  孙贵花;  孙敦陆
Adobe PDF(309Kb)  |  Favorite  |  View/Download:20/5  |  Submit date:2017/07/13