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Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma 期刊论文
CANCER RESEARCH, 2017, 卷号: 77, 期号: 18, 页码: 5068-5076
Authors:  Liu, Yan;  Li, Yuyang;  Wang, Xiaoen;  Liu, Feiyang;  Gao, Peng;  Quinn, Max M.;  Li, Fei;  Merlino, Ashley A.;  Benes, Cyril;  Liu, Qingsong;  Gray, Nathanael S.;  Wong, Kwok-Kin
Favorite  |  View/Download:10/0  |  Submit date:2018/08/16
Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 545-557
Authors:  Wang, Beilei;  Deng, Yuanxin;  Chen, Yongfei;  Yu, Kailin;  Wang, Aoli;  Liang, Qianmao;  Wang, Wei;  Chen, Cheng;  Wu, Hong;  Hu, Chen;  Miao, Weili;  Hur, Wooyoung;  Wang, Wenchao;  Hu, Zhenquan;  Weisberg, Ellen L.;  Wang, Jinhua;  Ren, Tao;  Wang, Yinsheng;  Gray, Nathanael S.;  Liu, Qingsong;  Liu, Jing
Favorite  |  View/Download:78/0  |  Submit date:2018/08/16
Btk  Kinase Inhibitor  Irreversible Inhibitor  Structure-activity Relationship  B-cell Lymphoma  
Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: 无, 页码: 1-10
Authors:  Wu, Hong;  Huang, Qiong;  Qi, Ziping;  Chen, Yongfei;  Wang, Aoli;  Chen, Cheng;  Liang, Qianmao;  Wang, Jinghua;  Chen, Wensheng;  Dong, Jin;  Yu, Kailin;  Hu, Chen;  Wang, Wenchao;  Liu, Xiaochuan;  Deng, Yuanxin;  Wang, Li;  Wang, Beilei;  Li, Xiaoxiang;  Gray, Nathanael S.;  Liu, Jing;  Wei, Wei;  Liu, Qingsong
View  |  Adobe PDF(3966Kb)  |  Favorite  |  View/Download:28/6  |  Submit date:2018/07/04
Ibrutinib targets mutant-EGFR kinase with a distinct binding conformation 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 43, 页码: 69760-69769
Authors:  Wang, Aoli;  Yan, Xiao-E;  Wu, Hong;  Wang, Wenchao;  Hu, Chen;  Chen, Cheng;  Zhao, Zheng;  Zhao, Peng;  Li, Xixiang;  Wang, Li;  Wang, Beilei;  Ye, Zi;  Wang, Jinhua;  Wang, Chu;  Zhang, Wei;  Gray, Nathanael S.;  Weisberg, Ellen L.;  Chen, Liang;  Liu, Jing;  Yun, Cai-Hong;  Liu, Qingsong
View  |  Adobe PDF(2026Kb)  |  Favorite  |  View/Download:31/9  |  Submit date:2017/11/21
Ibrutinib  Egfr Kinase  Dfg-in/c-helix-out  Inactive Conformation  Nsclc  
Identification of Wee1 and IGF-1R As Novel Therapeutic Targets for Mutant RAS-Driven Acute Leukemia By Combinatory Chemical Screens 期刊论文
BLOOD, 2014, 卷号: 124, 期号: 21, 页码: 3
Authors:  Nonami, Atsushi;  Zhao, Chen;  Liu Qingsong;  Cowens, Kristen;  Christie, Amanda L.;  Chen, Yongfei;  Sattler, Martin;  Wang, Kwok-Kin;  Gray, Nathanael S.;  Griffin, James D.;  Weisberg, Ellen L.
Favorite  |  View/Download:5/0  |  Submit date:2019/06/03
Exploration of Type II Binding Mode: A Privileged Approach for Kinase Inhibitor Focused Drug Discovery_ 期刊论文
ACS CHEMICAL BIOLOGY, 2014, 卷号: 9, 期号: 6, 页码: 1230-1241
Authors:  Zheng Zhao;  Hong Wu;  Li Wang;  Yi Liu;  Stefan Knapp;  Qingsong Liu;  Nathanael S. Gray
View  |  Adobe PDF(7391Kb)  |  Favorite  |  View/Download:32/5  |  Submit date:2016/11/23
Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer 期刊论文
ACS CHEMICAL BIOLOGY, 2013, 卷号: 8, 期号: 7, 页码: 1423-1428
Authors:  Liu, Feiyang;  Zhang, Xin;  Weisberg, Ellen;  Chen, Sen;  Hur, Wooyoung;  Wu, Hong;  Zhao, Zheng;  Wang, Wenchao;  Mao, Mao;  Cai, Changmeng;  Simon, Nicholas I.;  Sanda, Takaomi;  Wang, Jinhua;  Look, A. Thomas;  Griffin, James D.;  Balk, Steven P.;  Liu, Qingsong;  Gray, Nathanael S.
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Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase of a Potent and Selective DDR1 Receptor Tyrosine Kinase 期刊论文
ACS Chem. Biol., 2013, 卷号: 8, 页码: 2145-2150
Authors:  Hyung-Gu Kim,Li Tan,Ellen L. Weisberg,Feiyang Liu, Peter Canning,Hwan Geun Choi, Scott A. Ezell,Hong Wu, Zheng Zhao, Jinhua Wang, Anna Mandinova,James D. Griffin, Alex N. Bullock, Qingsong Liu,,‡ Sam W. Lee, Nathanael S. Gray
Adobe PDF(5958Kb)  |  Favorite  |  View/Download:207/70  |  Submit date:2014/07/30