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Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892
Authors:  Liang, Xiaofei;  Wang, Beilei;  Chen, Cheng;  Wang, Aoli;  Hu, Chen;  Zou, Fengming;  Yu, Kailin;  Liu, Qingwang;  Li, Feng;  Hu, Zhenquan;  Lu, Tingting;  Wang, Junjie;  Wang, Li;  Weisberg, Ellen L.;  Li, Lili;  Xia, Ruixiang;  Wang, Wenchao;  Ren, Tao;  Ge, Jian;  Liu, Jing;  Liu, Qinsong
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Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3K delta) inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 156, 页码: 831-846
Authors:  Liang, Xiaofei;  Li, Feng;  Chen, Cheng;  Jiang, Zongru;  Wang, Aoli;  Liu, Xiaochuan;  Ge, Juan;  Hu, Zhenquan;  Yu, Kailin;  Wang, Wenliang;  Zou, Fengming;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Zhang, Shanchun;  Wang, Yuxin;  Liu, Qingsong;  Liu, Jing
Favorite  |  View/Download:3/0  |  Submit date:2019/12/10
PI3K delta  Kinase inhibitor  Acute myeloid leukemia  Structure-activity relationship  
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxybenzamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 1793-1816
Authors:  Liang, Xiaofei;  Lv, Fengchao;  Wang, Beilei;  Yu, Kailin;  Wu, Hong;  Qi, Ziping;  Jiang, Zongru;  Chen, Cheng;  Wang, Aoli;  Miao, Weili;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Juan;  Liu, Xiaochuan;  Zhao, Zheng;  Wang, Li;  Zhang, Shanchuan;  Ye, Zi;  Wang, Chu;  Ren, Tao;  Wang, Yinsheng;  Liu, Qingsong;  Liu, Jing
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Simultaneous inhibition of Vps34 kinase would enhance PI3K delta inhibitor cytotoxicity in the B-cell malignancies 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 33, 页码: 53515-53525
Authors:  Liu, Xiaochuan;  Wang, Aoli;  Liang, Xiaofei;  Liu, Juanjuan;  Zou, Fengming;  Chen, Cheng;  Zhao, Zheng;  Deng, Yuanxin;  Wu, Hong;  Qi, Ziping;  Wang, Beilei;  Wang, Li;  Liu, Feiyang;  Xu, Yunhe;  Wang, Wenchao;  Fernandes, Stacey M.;  Stone, Richard M.;  Galinsky, Ilene A.;  Brown, Jennifer R.;  Loh, Teckpeng;  Griffin, James. D.;  Zhang, Shanchun;  Weisberg, Ellen L.;  Zhang, Xin;  Liu, Jing;  Liu, Qingsong
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Pi3k Delta  Vps34  Combination  Chronic Lymphatic Leukemia  Acute Myeloid Leukemia  
Characterization of selective and potent PI3K delta inhibitor (PI3KD-IN-015) for B-Cell malignances 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 22, 页码: 32641-32651
Authors:  Liu, Xiaochuan;  Wang, Aoli;  Liang, Xiaofei;  Chen, Cheng;  Liu, Juanjuan;  Zhao, Zheng;  Wu, Hong;  Deng, Yuanxin;  Wang, Li;  Wang, Beilei;  Wu, Jiaxin;  Liu, Feiyang;  Fernandes, Stacey M.;  Adamia, Sophia;  Stone, Richard M.;  Galinsky, Ilene A.;  Brown, Jennifer R.;  Griffin, James D.;  Zhang, Shanchun;  Loh, Teckpeng;  Zhang, Xin;  Wang, Wenchao;  Weisberg, Ellen L.;  Liu, Jing;  Liu, Qingsong
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Pi3k Delta  Leukemia  B-cell Malignances  Pi3k  Kinase Inhibitors  
Ammonia Induces Autophagy through Dopamine Receptor D3 and MTOR 期刊论文
PLOS ONE, 2016, 卷号: 11, 期号: 4, 页码: 1-24
Authors:  Li, Zhiyuan;  Ji, Xinmiao;  Wang, Wenchao;  Liu, Juanjuan;  Liang, Xiaofei;  Wu, Hong;  Liu, Jing;  Eggert, Ulrike S.;  Liu, Qingsong;  Zhang, Xin
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Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 5, 页码: 1984-2004
Authors:  Liang, Xiaofei;  Liu, Xiaochuan;  Wang, Beilei;  Zou, Fengming;  Wang, Aoli;  Qi, Shuan;  Chen, Cheng;  Zhao, Zheng;  Wang, Wenchao;  Qi, Ziping;  Lv, Fengchao;  Hu, Zhenquan;  Wang, Li;  Zhang, Shanchun;  Liu, Qingsong;  Liu, Jing
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PFOS-induced apoptosis through mitochondrion-dependent pathway in human-hamster hybrid cells 期刊论文
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2013, 卷号: 754, 期号: 1-2, 页码: 51-57
Authors:  Wang, Xiaofei;  Zhao, Guoping;  Liang, Junting;  Jiang, Jiang;  Chen, Ni;  Yu, Jing;  Wang, Qisen;  Xu, An;  Chen, Shaopeng;  Wu, Lijun
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Pfos  Apoptosis  Mutagenicity  Mtdna-depleted (Rho(0)) a(l) Cells  Oxidative Stress  
PFOS-induced apoptosis through mitochondrion-dependent pathway in human–hamster hybrid cells 期刊论文
Mutation Research, 2013, 卷号: 754
Authors:  Xiaofei Wang;  Guoping Zhao;  Junting Liang;  Jiang Jiang;  Ni Chen;  Jing Yu;  Qisen Wang;  An Xu;  Shaopeng Chen;  Lijun Wu
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