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Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
Authors:  Wu, Jiaxin;  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Qi, Ziping;  Hu, Chen;  Wang, Wenliang;  Wu, Hong;  Huang, Tao;  Zhao, Ming;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Li, Lili;  Ge, Jian;  Ren, Tao;  Xia, Ruixiang;  Liu, Jing
Favorite  |  View/Download:4/0  |  Submit date:2019/11/27
BCR-ABL  PDGFR  chronic myeloid leukemia  kinase inhibitor  
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
Authors:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
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ABL kinase  Kinase inhibitor  ABL mutant  CML  
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3K delta) inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 156, 页码: 831-846
Authors:  Liang, Xiaofei;  Li, Feng;  Chen, Cheng;  Jiang, Zongru;  Wang, Aoli;  Liu, Xiaochuan;  Ge, Juan;  Hu, Zhenquan;  Yu, Kailin;  Wang, Wenliang;  Zou, Fengming;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Zhang, Shanchun;  Wang, Yuxin;  Liu, Qingsong;  Liu, Jing
Favorite  |  View/Download:2/0  |  Submit date:2019/12/10
PI3K delta  Kinase inhibitor  Acute myeloid leukemia  Structure-activity relationship  
Discovery of 1-(4-(4-Amino-3-(4-(2-morpholinoethoxy)-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-3-(5-(tert-butyl)isoxazol-3-yl)urea (CHMFL-FLT3-213) as a Highly Potent Type II FLT3 Kinase Inhibitor Capable of Overcoming a Variety of FLT3 Kinase Mutants in FLT3-ITD Positive AML 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 20, 页码: 8407-8424
Authors:  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Wu, Hong;  Qi, Ziping;  Hu, Chen;  Yu, Kailin;  Wu, Jiaxin;  Liu, Juan;  Liu, Xiaochuan;  Hu, Zhenquan;  Wang, Wei;  Wang, Wenliang;  Wang, Wenchao;  Wang, Li;  Wang, Beilei;  Liu, Qingwang;  Li, Lili;  Ge, Jian;  Ren, Tao;  Zhang, Shanchun;  Xia, Ruixiang;  Liu, Jing;  Liu, Qingsong
View  |  Adobe PDF(10028Kb)  |  Favorite  |  View/Download:12/5  |  Submit date:2019/06/17
Critical dependence of magnetostructural coupling and magnetocaloric effect on particle size in Mn-Fe-Ni-Ge compounds 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6, 期号: 无, 页码: 1-10
Authors:  Wu, Rongrong;  Shen, Feiran;  Hu, Fengxia;  Wang, Jing;  Bao, Lifu;  Zhang, Lei;  Liu, Yao;  Zhao, Yingying;  Liang, Feixiang;  Zuo, Wenliang;  Sun, Jirong;  Shen, Baogen
View  |  Adobe PDF(2029Kb)  |  Favorite  |  View/Download:18/9  |  Submit date:2017/10/30
An ammonia sensor with high sensitivity in farmland based on laser absorption spectroscopy technology 会议论文
, Beijing, PEOPLES R CHINA, 2012
Authors:  Ying He;  Yujun Zhang;  Liming Wang;  Kun You;  Yanwei Gao;  Anning Zhu;  Wenliang Yang
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基于TDLAS-bLS方法的夏玉米农田氨挥发研究 期刊论文
光谱学与光谱分析, 2012, 卷号: 32, 期号: 11
Authors:  杨文亮;  朱安宁;  张佳宝;  张玉钧;  何 莹;  王立明;  陈效民;  陈文超
Adobe PDF(866Kb)  |  Favorite  |  View/Download:315/134  |  Submit date:2013/01/14
开放式农田氨气的高灵敏激光在线监测 期刊论文
光学学报, 2011, 卷号: 31, 期号: 6
Authors:  何 莹;  张玉钧;  朱安宁;  王立明;  阮 俊;  崔益本;  杨淑莉;  杨文亮;  吉丽青
Adobe PDF(2662Kb)  |  Favorite  |  View/Download:207/117  |  Submit date:2013/12/04