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Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) 期刊论文
CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885
Authors:  Wu, Jiaxin;  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Qi, Ziping;  Hu, Chen;  Wang, Wenliang;  Wu, Hong;  Huang, Tao;  Zhao, Ming;  Wang, Wenchao;  Hu, Zhenquan;  Liu, Qingwang;  Wang, Beilei;  Wang, Li;  Li, Lili;  Ge, Jian;  Ren, Tao;  Xia, Ruixiang;  Liu, Jing
Favorite  |  View/Download:11/0  |  Submit date:2019/11/27
BCR-ABL  PDGFR  chronic myeloid leukemia  kinase inhibitor  
Photo-enhanced gas sensing of SnS2 with nanoscale defects 期刊论文
RSC ADVANCES, 2019, 卷号: 9, 期号: 2, 页码: 626-635
Authors:  Yan, Wen-Jie;  Chen, Deng-Yun;  Fuh, Huei-Ru;  Li, Ying-Lan;  Zhang, Duan;  Liu, Huajun;  Wu, Gang;  Zhang, Lei;  Ren, Xiangkui;  Cho, Jiung;  Choi, Miri;  Chun, Byong Sun;  Coileain, Cormac O.;  Xu, Hong-Jun;  Wang, Zhi;  Jiang, Zhaotan;  Chang, Ching-Ray;  Wu, Han-Chun
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Effect of heat treatment processing on microstructure and tensile properties of Ti-6Al-4V-10Nb alloy 期刊论文
TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA, 2019, 卷号: 29, 期号: 1, 页码: 59-66
Authors:  Sun, Hong;  Yu, Li-ming;  Liu, Yong-chang;  Zhang, Li-ye;  Liu, Chen-xi;  Li, Hui-jun;  Wu, Jie-feng
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Ti-6Al-4V-10Nb alloy  heat treatment  microstructure  primary alpha phase  secondary alpha phase  strength  
The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China 期刊论文
CANCER MANAGEMENT AND RESEARCH, 2019, 卷号: 11, 期号: 无, 页码: 1473-1492
Authors:  Wu, Haibo;  Wang, Wei;  Du, Jun;  Li, Hong;  Wang, Huogang;  Huang, Liangliang;  Xiang, Hang;  Xie, Jing;  Liu, Xiaoli;  Li, Heng;  Lin, Wenchu
View  |  Adobe PDF(1845Kb)  |  Favorite  |  View/Download:133/128  |  Submit date:2020/05/21
breast cancer  PIK3CA  clinicopathological characteristics  prognosis  
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models 期刊论文
CANCER LETTERS, 2019, 卷号: 447, 页码: 105-114
Authors:  Lu, Tingting;  Chen, Cheng;  Wang, Aoli;  Jiang, Zongru;  Qi, Ziping;  Hu, Zhenquan;  Hu, Chen;  Liu, Feiyang;  Wang, Wenliang;  Wu, Hong;  Wang, Beilei;  Wang, Li;  Qi, Shuang;  Wu, Jiaxin;  Wang, Wenchao;  Tang, Jun;  Yan, Hezhong;  Bai, Mingfeng;  Liu, Qingsong;  Liu, Jing
Favorite  |  View/Download:0/0  |  Submit date:2020/07/14
cKIT T670I mutant  Activation loop mutants  Drug resistance  
Continuous-wave difference-frequency generation based on BaGa4Se7 crystal 期刊论文
OPTICS EXPRESS, 2019
Authors:  MING-GUO SUN;  ZHEN-SONG CAO;  JI-YONG YAO;  HONG-LIANG MA;  YANG-WU GUO;  XIAO-MING GAO;  RUI-ZHONG RAO,;  AND YI-CHENG WU
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Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 160, 页码: 61-81
Authors:  Liu, Xuesong;  Wang, Beilei;  Chen, Cheng;  Jiang, Zongru;  Hu, Chen;  Wu, Hong;  Zhang, Yicong;  Liu, Xiaochuan;  Wang, Wenliang;  Wang, Junjie;  Hu, Zhenquan;  Wang, Aoli;  Huang, Tao;  Liu, Qingwang;  Wang, Wei;  Wang, Li;  Wang, Wenchao;  Ren, Tao;  Li, Lili;  Xia, Ruixiang;  Ge, Jian;  Liu, Qingsong;  Liu, Jing
Adobe PDF(4593Kb)  |  Favorite  |  View/Download:126/89  |  Submit date:2019/01/11
ABL kinase  Kinase inhibitor  ABL mutant  CML  
Pulsed axial epitaxy of colloidal quantum dots in nanowires enables facet-selective passivation 期刊论文
NATURE COMMUNICATIONS, 2018, 卷号: 9, 页码: 8
Authors:  Li, Yi;  Zhuang, Tao-Tao;  Fan, Fengjia;  Voznyy, Oleksandr;  Askerka, Mikhail;  Zhu, Haiming;  Wu, Liang;  Liu, Guo-Qiang;  Pan, Yun-Xiang;  Sargent, Edward H.;  Yu, Shu-Hong
Favorite  |  View/Download:3/0  |  Submit date:2019/12/25
Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2018, 卷号: 81, 期号: 11, 页码: 2531-2538
Authors:  Wang, Qi;  Hu, Zhenquan;  Li, Xixiang;  Wang, Aoli;  Wu, Hong;  Liu, Jing;  Cao, Shugeng;  Liu, Qingsong
Favorite  |  View/Download:0/0  |  Submit date:2019/12/25
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
Authors:  Wang, Beilei;  Wu, Jiaxin;  Wu, Yun;  Chen, Cheng;  Zou, Fengming;  Wang, Aoli;  Wu, Hong;  Hu, Zhenquan;  Jiang, Zongru;  Liu, Qingwang;  Wang, Wei;  Zhang, Yicong;  Liu, Feiyang;  Zhao, Ming;  Hu, Jie;  Huang, Tao;  Ge, Juan;  Wang, Li;  Ren, Tao;  Wang, Yuxin;  Liu, Jing;  Liu, Qingsong
Favorite  |  View/Download:2/0  |  Submit date:2019/12/25
CDK9  Kinase inhibitor  Structure-activity relationship  Leukemia